SUPERCRITICAL FLUID TECHNOLOGY: AN INNOVATIVE APPROACH USED TO ENHANCE SOLUBILITY OF WATER INSOLUBLE DRUGS
Abstract
Certain techniques are used for the preparation of solid dispersions and used to enhance the solubility of water insoluble drugs. One of its techniques is supercritical fluid technology that is used for the preparation of solid dispersions. The present aim of this technique is to provide the recent advances in the use of supercritical fluids for the preparation of solid dispersion and for pharmaceutical substances with particular attention to drug delivery systems. Basically, a “supercritical fluid†can be defined as it enters in the pure substance when both temp. & pressure above its critical P&T. In the SCF techniques, there are certain solvents like CO2, N2O used as the supercritical fluid. This innovative technique is highly promising and approachable for the future applications in pharmaceutical industries.
Keywords: Supercritical fluids, solubility, solid dispersion, drug delivery, and Applications.
DOI
https://doi.org/10.22270/jddt.v7i5.1495References
Dalvi PB, Gerange AB, Ingale PR, Solid dispersion: strategy to enhance solubility, Journal of Drug Delivery and Therapeutics, 2015; 5(2):20-28
Shah DP, Patel B, Shah C, Nanosuspension technology: A innovative slant for drug delivery system and permeability enhancer for poorly water soluble drugs, Journal of Drug Delivery and Therapeutics, 2015; 5(1):10-23
Asadujjaman MD, Mishuk AU, Novel approaches in lipid based drug delivery systems, Journal of Drug Delivery and Therapeutics, 2013; 3(4):124-130
Mundhe AV, Cocrystalization: an alternative approach for solid modification, Journal of Drug Delivery and Therapeutics, 2013; 3(4):166-172
Gupta RB. Supercritical fluid technology for particle engineering, In: Gupta RB, Kompella UB editpors. Nanoparticle technologies for drug delivery, Volume 159 in Drugs and Pharmaceutical Sciences, Marcel Dekker, Inc, 2006, p 53-84.
Misra A, Jinturkar K, Patel D, Lalani J, Chougule M. Recent advances in liposomal dry powder formulations: preparation and evaluation. Expert Opin Drug Delivery. 2009; 6:71-89.
Pasquali I, Bettini R. Are pharmaceutics reallygoing supercritical? Int J Pharm. 2008; 364:176-187.
Duarte ARC, Duarte CMM, editors. Current Trends of the Supercritical Fluid Technology in the Pharmaceutical, Nutraceutical and Food Processing Industries. Bentham Books. eISBN: 978-1-60805-046-8, 2009
Pasquali I, Bettini R, Giordano F. Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals. Adv Drug Deliv Rev. 2008; 60:399-410.
Liu H, Pan WS, Zhou LL, Guo H. Supercritical fluid technology and its application in pharmaceutics. Acta pharmaceu Sinica. 2007; 41:1123-1129.
Bhardwaj. L, Sharma P.K., Visht S, Garg V.K., Kumar N A review on methodology and application of supercritical fluid technology in pharmaceutical industry. Der Pharmacia Sinica, 2010; 1 (3):183-194
Van Hees T, Piel G, Evrard B, Otte X, Thunus T, Delattre L. Application of supercritical carbon dioxide for the preparation of a piroxicam-beta-cyclodextrin inclusion compound. Pharm Res. 1999; 16(12):1864-1870.
Brunner G, In: Brunner G (ed.), Gas extraction. Steinkopff Darmstadt, Springer, New York, USA, 1994.
Gupta R.D, J Pharma Sci Res, 2008; 6 (2): 200-240
Krukonis V, Supercritical fluid nucleation of difficult to comminute solids, Proc. Annual Meeting AIChE, paper 140f, t-124, 1998.
Philips, E.M., Stella. V.J. Rapid Expansion from supercritical solutions: application to pharmaceutical Processes, Int J. Pharm, 1993; 94:1-10.
Meziani M.J, Pathak P, Beachman F, Allard L.F., Sun Y.P. Nanoparticle Formation in rapid expansion of water- in-supercritical carbon dioxide microemulsion into liquid solution, J. Supercritcal Fluids, 2001; 34:91-97.
Hanna .M, York P, WO95/01221, 1995.
York. P, Hanns. M, Shekunov Y.P., Humphreys, G.O. Microfine particles formation by SEDS (Solution enhanced Dispersion by Supercritical Fluids): scale up by design, Proc. Resp. Drug Delivery VI, 1998; 169-175.
Ker. J, Knez. S, Sen. P, Int J Pharm, 1999; 182, 1:33-39.
Moneghini M, Kikic I, Voinovich D, Perissutti B, Filipovic-Grcic J, Int J Pharm., 2001; 222(1):129-138.
Published
Abstract Display: 846 
PDF Downloads: 953 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.