FORMULATION AND EVALUATION OF CELECOXIB GEL

Abstract

The present research has been undertaken with the aim to develop a topical gel formulation of celecoxib, which would attenuate the gastrointestinal relater toxicities associated with oral administration and to investigate the effect of DMSO on permeation of celecoxib. Celecoxib is a highly selective cyclooxygenase-2 (cox-2) inhibitor.  In the present study gel with different concentrations of carbapol, sodium alginate and sodium carboxy methylcellulose were prepared. Gels were subjected for various evaluation tests such as pH measurement, spreadibility and extrudability. In-vitro dissolution studies were performed in phosphate buffer of pH 5.6 and polyethylene glycol 400 (7.4 pH) for 12 hrs by using Keshary-Chien diffusion cell apparatus. The gel formulation consisting of 7.5% w/w sodium alginate with DMSO found to be suitable for topical application based on in vitro evaluation. Sodium alginate based gels with DMSO revealed of 90% cumulative drug release after 12 hours. From the above observations, Sodium alginate seems to be a promising pharmaceutical adjuvant in the formulation of celecoxib gels