VALIDATED COLORIMETRIC METHODS FOR THE ESTIMATION OF TENELIGLIPTIN IN TABLETS
Abstract
Two simple sensitive and precise methods A and B were developed for the estimation of teneligliptin in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of a red colored chromogen by reaction of teneligliptin with potassium thiocyanate in presence of ferric chloride, which has an absorption maximum at 554nm.   Method B is based on the formation of an orange colored complex by complexation reaction of teneligliptin with 2, 2’- bipyridyl in the presence of ferric chloride which has an absorption maximum at 421nm. The proposed methods are statistically validated and found to be useful for the routine determination of teneligliptin in tablets.
Keywords: Teneligliptin, Colorimetry, Tablets, Validation
Â
DOI
https://doi.org/10.22270/jddt.v7i4.1467References
The Merck Index, An encyclopaedia of chemical drugs & biologicals. ed13, Merck research laboratories division of MERCK & CO., INC; 2001:P. 1703.
Martindale, the complete drug reference. ed 37, Vol. A. London, Pharmaceutical press; 2011: P. 551.
Tripathy KD. Essentials of Medical Pharmacology. Ed 6, Jaypee brothers Medical Publishers; 2010:P.172, 402,404.
Shanbhag T, Shenoy S. Pharmacology prepared manual for under graduates. ed 2, Reed Elsevier India Private limited; 2015:P.191, 196.
Indian Pharmacopoeia 2010, Vol lll, ed 6, Ghaziabad, Indian Pharmacopoeia Commission. P.2242.
Chitlange SS, Rawat DG, Chandani S, Estimation of Anti-diabetic Teneligliptin hydrobromide hydrate by RP-HPLC and Derivative Spectroscopy method, Indo American Journal of Pharmaceutical Research,2016; 6(7):P.6144-6153
Luhar SV, Pandya KR, Jani GK and Sachin Narkhed B.Simultaneous Estimation of Teneligliptin hydrobromide hydrate and its degradation product by RP-HPLC, Journal of Pharmaceutical Science and Bioscientific Research,2016; 6(3):254-261.
Chunduri BRH, Dannana GS, Development and validation of LC-MS/MS method for quantification of teneligliptin in human plasma and its application to a pharmacokinetic study,World Journal of Pharmacy and Pharmaceutical Sciences, 2016; 5(5):838-850.
Bakshi M, Singh S, Development of validated Stability-Indicating Assay Methods-Critical Review, Journal of Pharmaceutical and Biomedical Analysis, 2002; 28:1011-1040.
Published
Abstract Display: 732 
PDF Downloads: 810 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.