NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN
Abstract
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) and Hydroxy propyl methyl cellulose E3LV (HPMCE3LV), synthetic polymer to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared .Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.
DOI
https://doi.org/10.22270/jddt.v2i3.129
Published
14-05-2012
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1.
Pattewar SV, Patil DN, Bakade BV. NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2025 Mar. 16];2(3). Available from: https://jddtonline.info/index.php/jddt/article/view/129
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Research
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How to Cite
1.
Pattewar SV, Patil DN, Bakade BV. NATURAL POLYMER VIS A VIS SYNTHETIC POLYMER FOR SOLUBILITY ENHANCEMENT OF SIMVASTATIN. J. Drug Delivery Ther. [Internet]. 2012 May 14 [cited 2025 Mar. 16];2(3). Available from: https://jddtonline.info/index.php/jddt/article/view/129
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