FORMULATION AND EVALUATION OF ORAL FLOATING BEADS OF TRAMODOL HYDROCHLORIDE
Abstract
Aim of present work was to formulate and evaluate oral floating beads of Tramadol hydrochloride. Floating beads were fabricated using modified ionotropic gelation technique using various natural and synthetic polymers in different proportion. In the formulated batches BT1 to BT11 not have ability to extend drug release for 12 hours. In formulated batch BT 12 (Sodium alginate 6%: Carbapol 940 1.2 %) show in vitro release for 12 hours (100.26 ± 0.66% ). It also has floating lag time and floating time immediate, and floating duration more than 12 hours. In kinetic model fitting it follows Korsemeyers Peppas equation. Also it was found stable after 6 months in accelerated stability study. From all the formulation of oral floating beads of Tramadol Hydrochloride; it was concluded that, among all different polymer ratio Sodium Alginate 6% and CaCl2 3% (2:1 ratio) gives best results. Among different polymers Carbapol 940 gives retarded drug release for 12 hours. The optimized batch was found to be stable after 6 Months in accelerated stability studies.
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Key Words: Ionotropic gelation, Tramadol Hydrochloride, floating beads, Carbapol 940
DOI
https://doi.org/10.22270/jddt.v6i4.1270References
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