FORMULATION AND EVALUATION OF TASTE MASK ORALLY DISPERSIBLE PARACETAMOL TABLET

  • Ashish Prakash Gorle North Maharashtra University
  • Ritesh Bhagavansing Rajput Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research Shirpur, Dhule, M.H.- 425405, India

Abstract

Mostly the drugs are administered by oral route. Orally dispersible tablets are achieving importance when compared to novel oral drug delivery system. Orodispersible tablets are suitable for all age patients by masking the taste of drug. The objective of the present study was to optimize, formulate and evaluate orally dispersible tablet (ODT) of Paracetamol which disintegrates within few seconds in presence of saliva fluid by the use of super disintegrants.  Paracetamol is widely used over-the counter analgesic (pain reliever) and antipyretic (fever reducer). It is a very bitter drug so the patients unable to take orally; hence their bitter taste were masked. ODTs Formulations were prepared by Direct Compression and wet granulation method by the use of superdisintegrants and taste masking (F7;F8) is done by Eudragit EPO. The developed formulations were evaluated in terms of weight variation, drug content, friability, thickness, hardness, disintegration and in vitro dissolution test. Stability study of optimized formulation was also carried out as per ICH guidelines. The effects of disintegrants as well as binders in different concentration on the release profile of paracetamol ODTs were studied. The studied parameters were found to be satisfactory for all formulations. Disintegration time for the formulations was found to be less than 40 seconds. Disintegration time for all ODTs decreased with increase in disintegrant concentration. ODTs prepared using Avicel possessed least disintegration time (11s), offered better dissolution profile than that of all the ODTs formulations. Accelerated studies proved that the optimized formulation was stable even after three months.

Keywords: Orodispersible tablets, Paracetamol, Prosolv ODT; Eudragit EPO, physical characterization. in-vitro dissolution,

 

Keywords: Orodispersible tablets, Paracetamol, Prosolv ODT, Eudragit EPO, physical characterization. in-vitro dissolution,

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Author Biographies

Ashish Prakash Gorle, North Maharashtra University
Pharmaceutics and Associate prof.
Ritesh Bhagavansing Rajput, Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research Shirpur, Dhule, M.H.- 425405, India

Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research Shirpur, Dhule, M.H.- 425405, India

References

1. Paul Y, Tyagi S, Singh B, Formulation and Evaluation of Oral Dispersible Tablets of Zidovudine with different Superdisintegrants, International Journal of Current Pharmaceutical Review and Research, 2011, 2(2), 80-85.
2. https://en.wikipedia.org/wiki/Orally_disintegrating_tablet
3. ITANMOY GHOSH*, AMITAVA GHOSH AND DEVI PRASAD, A review on new generation orodispersible tablets and its future prospective. International Journal of Pharmacy and Pharmaceutical Sciences, 2011; 3(1):1-7.
4. Chotaliya MB, Chakraborty S, Overview of Oral Dispersible Tablets. International Journal of PharmTech Research, 2012,4(4),1712-20.
5. Pokhariya P, Ganarajan G, Kothiyal P, MOUTH DISSOLVING TABLET: REVIEW,2015, 4(11), 750-767.
6. Garg A, Gupta MM, Taste masking and formulation development & evaluation of mouth dissolving tablets of levocetrizine dihydrochloride, Journal of Drug Delivery & Therapeutics, 2013, 3(3), 123-130.
7. http://www.jrspharma.com/pharma_en/products-services/excipients/hfe/prosolv-odt-g2.php.
8. http://www.pharma-ingredients.basf.com/documents/enp/brochure/en/basf_kollidon_grades.pdf.
9. Danagi PM, Halakatti PK, Mastiholimath VM, Patil M.B, Manvi FV, Rapidly disintegrating domperidone tablets. Indian Drugs 2006, 43(7), 594-97.
10. Shishu, Bhatti A, Singh T. Preparation of tablets rapidly disintegrating in saliva containing bitter taste masked granules by compression method. Indian Journal of Pharmaceutical Sciences, 2007, 69(1), 80-84.
11. Jadon RS, Nayak S, Amlan S, Vaidya VD, Khemariya P, Sumbhate S, Nayak S, Taste masking of Lornoxicam by polymer carrier system and formulation of oral disintegrating tablets, International Journal of Drug Delivery, 2009, 1, 27-31.
12. Sreenivas SA, Gadad AP. Formulation and evaluation of Ondancetron Hcl directly compressed mouth disintegrating tablets. Indian Drugs, 2006, 43(1), 35-38.
13. Bi Y, Sunanda H, Yonezawa Y, Danjo K, Otsuka A, Iida K. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chemical and Pharmaceutical Bulletin, 1996, 44, 2121-2127.
14. Reddy LH, Gosh BR. Fast dissolving drug delivery system: A Review of the literature. Indian Journal of Pharmaceutical Sciences, 2002, 64,331-336.
15. Narazaki R, Harada T, Takami N, Kato Y, Ohwaki T, A new method for disintegration studies of rapid disintegrating tablet.Chemical & Pharmaceutical Bulletin (Tokyo). 2004, 52(6), 704-7.
16. Bandari S, Mittapalli RK, Gannu R, Rao YM. Orodispersible tablets: An overview. Asian Jornal of Phamacutics. 2008,2, 2–11.
17. Paramita Dey and Sabyasachi Maiti. Orodispersible tablets: A new trend in drug delivery. Journal of Natural Science Biology and Medcine. 2010 Jul-Dec; 1(1): 2–5.
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Gorle A, Rajput R. FORMULATION AND EVALUATION OF TASTE MASK ORALLY DISPERSIBLE PARACETAMOL TABLET. JDDT [Internet]. 14Mar.2016 [cited 5Aug.2021];6(2):30-6. Available from: https://jddtonline.info/index.php/jddt/article/view/1224