FORMULATION & CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIER (NLC) BASED GEL FOR TOPICAL DELIVERY OF ETORICOXIB

  • Anupam Kumar Sachan Dayanand Dinanath College, Institute of Pharmacy, NH#86 Hamirpur Road, Kanpur-209214
  • Ankita Gupta
  • Mona Arora Dayanand Dinanath College, Institute of Pharmacy, Kanpur-209214(INDIA)

Abstract

Nanostructured lipid carriers (NLC)-based topical gel of Etoricoxib was prepared with the aim for the treatment of inflammation and allied conditions.  The composition of NLC consisted of Stearic acid as solid lipid, oleic acid as liquid lipid and tween 80 as a surfactant. NLCs prepared by melt-emulsification and low temperature solidification techniques were characterized by particle sizing technology, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). All of the NLC showed high entrapment efficiency ranging from 69% to 76%. Both the entrapment and release rate were affected by the percentage of oleic acid. NLC-F3G-C was selected as best formulation with average particle size of 244 nm and polydispersity index of 0.690 indicating homogeneity in particle size distribution. The higher magnitude of zeta potential of NLC-F3G-C indicates the stability of formulation. The nanoparticulate dispersion was suitably gelled and assessed for Physical appearance, Homogeneity, Spreadability and in-vitro permeation study. In-vitro drug release pattern of developed NLC dispersion gel showed burst and prolong release. It was concluded that developed NLC gel of Etoricoxib holds promise for prolonged availability of drug in the skin tissues and can be used for better management of inflammatory conditions.

Keywords: Etricoxib • Nanostructured lipid carriers (NLC) • Topical gel • Nanoparticl

Downloads

Download data is not yet available.

Author Biographies

Ankita Gupta

Dayanand Dinanath College, Institute of Pharmacy, Kanpur-209214(INDIA)

Mona Arora, Dayanand Dinanath College, Institute of Pharmacy, Kanpur-209214(INDIA)

Dayanand Dinanath College, Institute of Pharmacy, Kanpur-209214(INDIA)

References

1. Müller RH, Mäder K, Gohla S, Solid lipid nanoparticles (SLN) for controlled drug delivery –a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50 (a), 161-177.
2. Sachan AK, Gupta A, A review on nanotized herbal drugs, IJPSR, 2015, 6(3), 961-970.
3. Patravale VB, Date AA, Kulkarni RM, Nanosuspensions: a promising drug delivery strategy, Journal of Pharmacy and Pharmacology, 2004, 56, 827-840.
4. Müller RH, Mehnert W, Lucks JS, Schwarz C, Rühl D, Solid lipid nanoparticles(SLN)-an alternative colloidal carrier system for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 1995, 41, 62-69.
5. Joshi M, Patravale V, Nanostructure lipid carrier (NLC) based gel of celecoxib, Int J Pharm, 2008, 346,124-132.
6. Sahu MK, Soni GC, Prajapati SK, Nanostructured Lipid Carrier: The Second Generation of Solid Lipid Nanoparticle, IJPRS, 2012, 1(3), 224-235.
7. Krishnaiah YSR, Satyanarayan V, Kartikeyan RS, Penetration enhancing effect of methanolon the percutaneous absorption of nicardipine hydrochloride from HPC gel through excised rat epidermis, Pharm. Dev. Tech, 2002,7, 305-316.
8. Marzouk M, Abd El- H, Kassem A, El-Din A, In-vitro release, Thermodynamics and Pharmacodynamic Studies of Aceclofenac Transdermal Eudragit Patches, Drug Invention Today, 2009, 1(1), 16-22.
9. Pozzo AD, Donzelli G, Liggeri E, Rodriguez L, Percutaneous absorption of nicotinic acid derivatives in-vitro, J. Pharm. Sci,1991, 80, 54-57.
10. Patel D, Dasgupta S, Dey S, Ramani YR, Ray S, Mazumder B, Nanostructured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Characterization, and In Vivo Evaluation, Sci Pharm. 2012, 80, 749–764.
11. Jain P, Mishra A, Yadav SK, Patil UK, Baghel US, Formulation Development and Characterization of Solid Lipid Nanoparticles Containing Nimesulide, International Journal of Drug Delivery Technology, 2009, 1(1), 24-27.
12. Lankalapalli S, Routhu KC, Ojha S, Tenneti VSVK, Nanoparticulate Drug Delivery Systems: Promising Approaches For Drug Delivery, JDDT; Special Issue1: Drug Delivery using Nanomedicine & Nanotechnology 2014, 72-85.
13. Teeranachaideekul V, Müller RH, Junyaprasert VB, Encapsulation of ascorbylpalmitate in nanostructured lipid carriers (NLC)- effects of formulation parameters on physicochemical stability, Int J Pharm, 2007, 340(1-2), 198-206.
14. Sanad AR, Abdelmalak NS, Formulation of novel oxybenzone-loaded nanostructured lipid carriers (NLCs), AAPS. PharmScitech, 2010, 11, 1684–1694.
15. Nasr M, Mansour S, Mortada ND, Lipospheres as Carriers for Topical Delivery of Aceclofenac: Preparation, Characterization and In Vivo Evaluation, AAPS PharmSciTech. 2008, 9(1), 154-62.
16. Slavomira D, Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC), Colloids and Surfaces B: Biointerfaces, 2010, 75, 538–542.
17. Bhasker K, Anbu J, Lipid nanoparticles for transdermal delivery of flurbiprofen- Formulation, in-vitro, ex-vivo and in-vivo studies, Lipid in health and disease, 2009, 8(6), 1-15.
18. Mazumder B, Dey S, Bhattacharya S, Sarkar S, Mohanta B, Studies on formulation and characterization of cellulose-based microspheres of chlorpheniramine maleate, Arch Pharm Sci& Res, 2009, 1, 66-74.
19. Sachan NK, Bhattacharya A, Modeling and characterization of drug release from glutinous rice starch based hydrogel beads for control drug delivery, Int. J. of health research, 2009, 2(1), 93-99.
20. Bhalekar MR, Pokharkar V, Madgulkar A, Patil N, Preparation and Evaluation of Miconazole Nitrate-Loaded Solid Lipid Nanoparticles for Topical Delivery, AAPS PharmSciTech. 2009, 10(1), 289-96.
21. Sood A, Panchagnula R, Drug Release evaluation of diltiazem CR preparation, Int. J. of pharmaceutics, 1998, 175, 95-107.
22. Das A, Nayak AK, Mohanty B, Panda S, Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers, Int Sch Res Net, 2011, 819765, 1-8.
23. Sachan AK, Gupta A, Nigam L, Sharma R, Gangwar SS, Design and characterization of solid dispersion based fast dissolving tablet of Cetirizine hydrochloride, MIT International Journal of Pharmaceutical Sciences, 2015, 1(1), 37-44.
24. Budavari S, Neil M, Smith JO, Heckelma P, Kinneary JF, The Merck Index, an Encyclopedia of Chemicals, Drugs and Biologicals. Whitehouse station, NJ, Merck and Co, 1996.
25. Jia L, Zhang D, Nanostructured lipid carrier for parenteral delivery of silybin: biodistribution and pharmacokinetic studies, colloids and surface B: Biointerfaces, 2010, 80, 213-218.
26. Hou D, Xie C, Huang K, Zhu C, The production and characteristics of solid lipid nanoparticles (SLNs), Biomaterials, 2003, 24, 1781–178.
27. Arora M, Preparation & evaluation of nanostructured lipid carrier (NLC) based gel for topical delivery of etoricoxib, M.Pharm thesis submission, Dayanand Dinanath College, Institute Of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, India, 2016.
Statistics
1239 Views | 703 Downloads
How to Cite
1.
Sachan A, Gupta A, Arora M. FORMULATION & CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIER (NLC) BASED GEL FOR TOPICAL DELIVERY OF ETORICOXIB. JDDT [Internet]. 14Mar.2016 [cited 26Oct.2021];6(2):4-3. Available from: https://jddtonline.info/index.php/jddt/article/view/1222