FLAXSEEDS AND AJWAIN FOR PRIMARY HYPERLIPIDEMIA

  • DR. GULSHAN ARA JALBANI Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • DR. SHAHEENA HAKRO Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • DR. SHAH MURAD Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • DR. KHALID NIAZ Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • DR. ABDUL QUDOOS Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • HAFIZ MOEEN-UD-DIN Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
  • DR. AJAZ FATIMA Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Abstract

Research work was single blind placebo-controlled, conducted at General Hospital, Lahore, Pakistan conducted from NOVEMBER 2015 to JANUARY 2016. 75 diagnosed primary  hyperlipidemic patients were selected with age range from 20 to 60 years. Diabetes mellitus, cigarette smoking/alcohol addictive patients, peptic ulcer disease, hypothyroidism, kidney dysfunction, any heart disease and liver disease. All patients were divided in three groups, ie;  25 in each group. All participant’s baseline lipid profile data were taken and filed in specifically designed Performa, at start of taking medicine. Twenty five patients of group-I were advised to take 10 grams of Flaxseeds in three divided doses after meal. Twenty five patients of group-II were advised to take Ajwain seeds 10 grams in three divided doses after each meal for two months. Twenty five patients of group-III were provided placebo capsules, (containing grinded rice), taking one capsule after each meal. All participants were advised to take these medicines for eight weeks. Followup period: All participants were called fortnightly for their query and  follow up. Their LDL-cholesterol, and HDL-cholesterol was determined at the hospital laboratory. In two months therapy by Flaxseeds decreased LDL-cholesterol 6.2 % and increased HDL-cholesterol 7.7 %. Ajwain reduced LDL-cholesterol 8.9 % and HDL-cholesterol increased 13.1 %. All changes are biostatistically significant with p-value of <0.01. Conclusion: It was concluded from the research that both Flaxseeds and Ajwain are effective in Primary Hyperlipidemia, if used for two months with specific concentrations.

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Author Biographies

DR. GULSHAN ARA JALBANI, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan
Shah Murad, Professor/HOD PharmacologyIslamabad Medical & Dental College, Islamabad, Pakistan
DR. SHAHEENA HAKRO, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

DR. SHAH MURAD, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

DR. KHALID NIAZ, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

DR. ABDUL QUDOOS, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

HAFIZ MOEEN-UD-DIN, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

DR. AJAZ FATIMA, Shah Murad, Professor/HOD Pharmacology Islamabad Medical & Dental College, Islamabad, Pakistan

Shah Murad, Professor/HOD Pharmacology

Islamabad Medical & Dental College, Islamabad, Pakistan

References

1. Trompet S, Van Vliet P, de Craen AJ, et al. Pravastatin and CAD in the elderly. Results of the PROSPER study. J Neurol. 2010;257:85-90.

2. Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM. Coronary Artery Disease and Hyperlipidemia: analysis of 60 case reports and review of the literature. Pharmacotherapy 2013;23:871-80.

3. Srivastava KC. Extract of a spice-omum (Trachyspermum ammi shows antiaggregatory effects and alters arachidonic acid metabolism in human platelets. Prostaglandins Leukot Essent Fatty Acids 2011;33:16.
4. Feldman HH, Doody RS, Kivipelto M, et al. Randomized controlled trial of atorvastatin in mild to moderate hyperlipidemia. Neurology 2010;74:956-964.

5.Orsi A, Sherman O, Woldeselassie Z. Simvastatin-associated memory loss. Pharmacotherapy 2011;21:767-9.

6. Chialva F, Monguzzi F, Manitto P, Akgül A. Essential oil constituents of Trachyspermum copticum (L.) and Lipid Metabolism. J Essent Oil Res. 2012;5:105-6.
7. Patenaude, A., Rodriguez-Leyva, D., Edel, A. L., Dibrov, E., et al., Bioavailability of a-linolenic acid from flaxseed diets as a function of the age of the subject. Euro. J. Clin. Nutri. 2009;63:1123–1129.
8. Krishnamoorthy V, Madalageri MB. Bishop weeds (Trachyspermum ammi): An essential crop for north Karnatka. J Med Aromat Plant Sci. 2010;21:996–8.
9. Rodriguez-Leyva, D., Bassett, C. M., Mccullough, R., Pierce, G. N., The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Can. J. Cardiol. 2010;26:489-496.
10. K. Zomorodian, M. R. Moein, M. J. Rahimi et al., “Possible application and chemical compositions of flaxseed essential oils against food borne and nosocomial pathogens,” Middle-East Journal of Scientific Research 2011;9(2): 239-45.

11. G. Singh, S. Maurya, C. Catalan, and M. P. de Lampasona, “Chemical constituents, antifungal and antioxidative effects of ajwain essentials oil and its acetone extract,” Journal of Agricultural and Food Chemistry 2004;52(11): 3292–96.

12. Anilakumar KR, Saritha V, Khanum F, Bawa AS. Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation. Food Chem Toxicol. 2009;47:279-82.

13. M. Khajeh, Y. Yamini, F. Sefidkon, and N. Bahramifar, “Comparison of essential oil composition of Carum copticum obtained by supercritical carbon dioxide extraction and hydrodistillation methods,”Food Chemistry 2010;86(4):587–591.
14. A. Mohagheghzadeh, P. Faridi, and Y. Ghasemi, “Carum copticum Benth. & Hook., essential oil chemotypes,” Food Chemistry 2007;100(3):1217–19.
15. Arjmandi B, Khan D, Juma S, et al. Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein (a) concentrations in postmenopausal women. Nutrition Research 2011; 18(7):1203-14.
16. Prasad K. Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed. Atherosclerosis 2008;179(2):269-275.
17. Kelley, D. S., Siegel, D., Vemuri, M., Mackey, B. E., Flaxseeds improve fasting and postprandial lipid profiles in hyperlipidemic men. Am. J. Clin. Nutr. 2009;86:324-333.
18. Cho Y, Kwon E, Kim H, et al. Low trans structured fat from flaxseed oil improves plasma and hepatic lipid metabolism. Food and Chemical Toxicology 2009;47(7):1550-55.
19. Jenkins D, Kendall C, Vidgen E, et al. Health aspects of partially defatted flaxseed, including effects on serum lipids, and oxidative stress: a controlled crossover trial. American Journal of Clinical Nutrition 2010;69(3):395.
20. Nagalakshmi S, Shankaracharya NB, Naik JP, Rao LJM. Studies on chemical and technological aspects of ajowan (Trachyspermum ammi syn. Carum copticum) J Food Sci Technol. 2011;37:277–81.
21. Tzang, B. S., Yang, S. F., Fu, S. G., Yang, H. C., et al., Effects of AJWAIN on cholesterol metabolism. Food Chem. 2009;114:1450-55.
22. Ishikawah T, Sega Y, Kitajima J. Water-soluble constituents of ajowan. Chem Pharm Bull. 2011;49:840-4.
23. Murthy PS, Borse BB, Khanum H, Srinivas P. Inhibitory effects of Ajwain (Trachyspermum ammi) ethanolic extract on A. ochraceus growth and ochratoxin production. Turk J Biol. 2009;33:211–7.
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JALBANI DGA, HAKRO DS, MURAD DS, NIAZ DK, QUDOOS DA, MOEEN-UD-DIN H, FATIMA DA. FLAXSEEDS AND AJWAIN FOR PRIMARY HYPERLIPIDEMIA. JDDT [Internet]. 14Mar.2016 [cited 26Sep.2021];6(2):37-9. Available from: https://jddtonline.info/index.php/jddt/article/view/1203