• Himanshu P.S Gurjar Shri Ramnath College of Pharmacy Gwalior MP.India.
  • Dr. Raghuveer Irchhaiya Institute of Pharmacy, Department of Pharmacognosy, Bundelkhand University, Jhansi UP, India.
  • Dr. Amita Vermas Institute of Pharmacy, Department of Pharmaceutical Sciences Allahabad Agricultural University, Shiats UP, India.


In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. Many traditional medicines in use are derived from medicinal plants, minerals and organic matter .The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Among these 2500 species are in India, out of which 150 species are used commercially on a fairly large scale. India is the largest producer of medicinal herbs and is called as botanical garden of the world .The current review focuses on herbal drug preparations and plants used in the treatment of different chronic dieses in the world. The use of Ayurvedic medicines is common in both adults and children and is increasing in many areas of the world. This paper will discuss the benefits with use of herbal medicines as Antidiabetic activity.


KEYWORDS: Medicinal plant, Antidiabetic activity, Diabetes mellitus


Download data is not yet available.

Author Biographies

Himanshu P.S Gurjar, Shri Ramnath College of Pharmacy Gwalior MP.India.

Shri Ramnath College of Pharmacy Gwalior MP.India.

Dr. Raghuveer Irchhaiya, Institute of Pharmacy, Department of Pharmacognosy, Bundelkhand University, Jhansi UP, India.

Institute of Pharmacy, Department of Pharmacognosy, Bundelkhand University, Jhansi UP, India.

Dr. Amita Vermas, Institute of Pharmacy, Department of Pharmaceutical Sciences Allahabad Agricultural University, Shiats UP, India.

Institute of Pharmacy, Department of Pharmaceutical Sciences Allahabad Agricultural University, Shiats UP, India.


1. Nair SA, Shylesh BS, Gopakumar B, Subramoniam A. Antidiabetes and hypoglycaemic properties of Hemionitis arifolia (Burm.) Moore in rats. Journal of Ethnopharmacology 2006; 106: 192–197.
2. Sarah W, Anders G, Sicree R, King H. Global Prevalence of Diabetes: epidemiology/health services/psychosial research. Diabetes Care 2004; 27: 1047-53.
3. Jared Diamond. Diabetes in India. Nature 2011; 46:469.
4. Safdar M, Khan A, Khan MMA, Siddique M. Effect of Various Doses of Cinnamon on Blood Glucose in Diabetic Individuals. Pakistan Journal of Nutrition 2004; 3:268-272.
5. Ramachandran A, Das AK, Joshi SR, Yajnik CS, Shah S, Prasanna KM. Current status of Diabetes in India and need for Novel therapeutic agent. Journal of Association of Physician of India 2010;58; 7-9
6. (accessed Aug16, 2011)
7. Umara A, Qamar U, Bala Y, Bashar Bello MS. Anti-hyperglycemic activity of the leaves of Tetracera scandens (Dilleniaceae) in alloxan induced diabetic rats. Journal of Ethnopharmacology 2010; 131:140–145.
8. Arulrayan N, Rangasamy S, James E, Pitchai D. A database for medicinal plants used in the treatment of diabetes and its secondary complications. Bioinformation 2007; 2:22 -23.
9. Thomas, M.C. Diuretics, ACE inhibitors and NSAIDs – the triple whammy. Medical Journal of Australia, 2000; 172: 184-185.
10. Vittalrao AM, Shanbhag T, Kumari KM, Bairy KL and Shenoy S, Evaluation Of Antiinflammatory And Analgesic Activities Of Alcoholic Extract Of Kaempferia Galanga In Rats, Indian J Physiol Pharmacol, 2011; 55(1): 13–24.
11. Mojekwu TO, Yama OE, Ojokuku SA, Oyebadejo SA. Hypoglyceamic effects of aqueous extract of Aframomum melegueta leaf on alloxan-induced diabetic male albino rats. Pacific Journal of Medical Sciences 2011; 8:28-36.
12. Noor A, Gunasekaran S, Soosai A, Minicab, Vijayalakshmi MA. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin induced diabetic rats. Current science 2008; 94:1070-1076.
13. Rehman SU, Jafri SA, Hassan S, Ishtiaq N, Muhammad N. Study on antidiabetic effect of Aloe vera extract on alloxan induced diabetic rats. Libyan Agriculture Research Center Journal International 2011; 2: 29-32.
14. Chattopadhyay RR. Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Journal of Ethnopharmacology 1999; 67:373–376.
15. Modak M, Dixit P, Londhe J, Ghaskadbi J, Paul T, Devasagayam A. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007; 40:163–173.
16. Yaheya M, Ismail M. Clinical Evaluation of Antidiabetic Activity of Bael leaves. World applied sciences journal 2009; 6:1518-1520.
17. Sokeng SD, Lontsi D, Moundipa PF, Jatsa HB, Watcho P, Kamtchouing P. Hypoglycemic effect of Anacardium occidentale methanol extract and fractions on streptozotocin-induced diabetic rats. Global Journal of Pharmacology 2007; 1:01-05.
18. Lawrence AO, Okwusidi JI, Ayodele OS. Antidiabetic, Effect of Anacardium occidentale stem bark in fructose diabetic rats, Pharmaceutical Biology 2005; 43:589–593.
19. Nirmala A, Saroja S, Vasanthi HR, Lalitha G. Hypoglycemic effect of Basella rubra in streptozotocin – induced diabetic albino rats. Journal of Pharmacognosy and Phytotherapy 2009; 1:025-030.
20. Grace IA, Oluwakemi TA, Bamidele VO, Ayodele OS. Anti-diabetic Properties of the aqueous leaf extract of Bougainvillea glabra (Glory of the Garden) on Alloxan-Induced Diabetic Rats. Rec Nat Prod 2009; 3:187-192.
21. Adaobi CE, Peter AA, Charles CO, Chinwe BO. Experimental evidence for the antidiabetic activity of Cajanus cajan leaves in rats. Journal of Basic and Clinical Pharmacy 2010; 1:81-84.
22. Shibib BA, Khan LA, Rahman R. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6- phosphatase and fructose-1, 6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993; 292: 267-270.
23. Emmanuel S, Sheeba Rani, Raja Sreekanth. Antidiabetic activity of Cassia occidentalis in streptozotocin-induced diabetic rats: a dose dependent study. International journal of pharma and bio sciences 2010; 1: 1-12.
24. Sophia D, Manoharan S. Hypolipidemic activities of ficus racemosa linn bark in alloxan induced diabetic rats. Afr. J. Trad. CAM, 2007; 4 (3): 279 – 288.
25. Tanko Y, Yerima M, Mahdi MA, Yaro AH, Musa KY, Mohammed A. Hypoglycemic Activity of Methanolic Stem Bark of Adansonnia digitata extract on blood glucose levels of Streptozotocin-induced Diabetic wistar rats. International Journal of Applied Research in Natural Products, 2008; 1(2):32-36.
26. Oyedemi SO, Adewusi EA, Aiyegoro OA, Akinpelu DA. Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin-induced diabetic wistar rats. Asian Pacific Journal of Tropical Biomedicine 2011: 353-358.
27. Keshri Umashanker PD, Chandra S, Janardan S, antidiabetic efficacy of ethanolic extract of holarrhena antidysenterica seeds in streptozotocin – induced diabetic rats and it’s influence on certain biochemical parameters, Journal of Drug Delivery & Therapeutics; 2012, 2(4), 159-162.
28. Lanjhiyana S, Garabadu D, Ahirwar D, Bigoniya P, Rana AC, Patra KC et al. Antidiabetic activity of methanolic extract of stem bark of Elaeodendron glaucum in alloxanized rat model. Advances in applied science research, 2011; 2(1): 47-62.
29. Ragavan B, Krishnakumari S. Antidiabetic effect of T. Arjuna bark extract in alloxan induced diabetic rats. Indian Journal of Clinical Biochemistry, 2006; 21(2): 123-128.
30. Velmurugan C, Sundaram T, Sampath RK, Vivek B, Sheshadri S, Kumar A. Anti diabetic and hypolipidemic activity of bark of ethanolic extract of Ougeinia oojeinensis (ROXB.). Med J Malaysia 2011; 66: 22-26.
31. Parthasarathy R, Ilavarasan R, Karrunakaran CM. Antidiabetic activity of Thespesia Populnea bark and leaf extract against streptozotocin induced diabetic rats. International Journal of PharmTech Research, 2009; 1: 1069-1072.
32. Keshari A, Tripathi PK, Srivastava A, Vishwas R, Formulation and evaluation of effervecent floating tablets of antidiabetic drug, Journal of Drug Delivery & Therapeutics. 2015; 5(6):43-55
33. Sharma V, Samantha KC, Pooja. Hypoglycemic activity of methanolic extract of Tectona grandis linn. root in alloxan induced diabetic rats. Journal of Applied Pharmaceutical Science, 2011; 1: 106-109.
34. Mashirkar VJ, Deshmukh VN, Jadhav JK, Sarkar DK. Anti diabetic activity of the ethanolic extract of Pseudarthria viscida root against alloxan induced diabetes in albino rats. Research J Pharm and Tech, 2008; 1: 541-546.
35. Sharma V, Marwaha A, Pooja. Hypoglycemic activity of methanolic extracts of Nyctanthes arbortristis linn root in alloxan induced diabetic rats. Int J Pharm Pharm Sci 2011; 3:210-212.
36. Xie JT, Mehendale S, Yuan CS. Ginseng and Diabetes. American Journal of Chinese Medicine 2005; 33: 397–404.
37. Kumar V, Khanna AK, Khan MM, Singh R, Singh S, Chander R et al. hypoglycemic, lipid lowering and antioxidant activities in root extract of Anthocephalus indicus in alloxan induced diabetic rats, Ind J Clin Biochem 2009; 24 (1): 65-69.
38. Djomeni PD, Ledong T, Asongalem EA, Dimo T, Sokeng SD, Kamtchouingc P. Hypoglycaemic and antidiabetic effect of root extracts of Ceiba pentandra in normal and diabetic rats. Afr. J. Trad. Cam 2006; 3: 129 – 136.
39. Mujeeb M, Khan SA, Mohd A, Mall A, Aftab A. Antidiabetic activity of the aqueous extract of Annona squamosa in streptozotocin induced- hyperglycemic rats, T. Pharm. Res. 2009; 2: 59-63.
40. Bhaskar V.H, Singh SA. Antihyperglycemic and Antihyperlipidaemic activities of root extracts of Calotropis procera on streptozotocin induced diabetic rats. Jordan Journal of Biological Sciences 2009; 2: 177-180.
41. Monago CC, Alumanah EO. Antidiabetic effect of Chloroform methanol extract of Abrus Precatorius seed in alloxan diabetic rabbit. J Appl Sci Environ Mgt 2005; 9(1):85 – 88.
42. Chaturvedi A, Bhawani G, Agarwal PK, Goel S, Singh A, Goel RK. Antidiabetic and Antiulcer effects of extract of Eeugenia jambolana seed in mild diabetic rats: study on gastric mucosal offensive acid-pepsin secretion. Indian J Physiol Pharmacol 2009; 53: 137–146.
43. Adeneyea AA, Olagunjub JA. Preliminary hypoglycemic and hypolipidemic activities of the aqueous seed extract of Carica papaya in wistar rats. Biology and Medicine 2009; 1: 1-10.
44. Abdallah IZ. Evaluation of Hypoglycemic Activity of Opuntia dillenii Haw Fruit Juice in Streptozotocin-Induced diabetic rats. The Egyptian Journal of Hospital Medicine 2008; 33: 544– 558.
45. Qureshi SA, Warda A, Sultana V. The Effect of Phyllantus emblica on Type - II Diabetes, Triglycerides and Liver - Specific Enzyme. Pakistan Journal of Nutrition 2009; 8:125-128.
46. Dikshit M, Rachh PR, Nayak BS, Shah BN, Modi KP, Patel NM et al. Antihyperlipidemic acitivity of Syzygium cumini seed extract on high cholesterol fed diet rats. Int J Ph Sci 2009; 1:330-332.
47. Chen KK, Robert CA, McCowen MC, Harris PN. Pharmacological action of hypoglycin A & B. The J Phar Exp Pharmacol 1957; 121:272-285.
48. Luoa Q, Yizhong C, Yana J, Sunc M, Corkeb H. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sciences 2004; 76: 137–149.
49. Singh SN, Vats P, Suri S, Shyam R, Kumria MML, Ranganathan S et al. Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. Journal of Ethnopharmacology 2001; 76:269–277.
50. Ozougwu JC. Anti-diabetic effects of Allium cepa (onions) aqueous extracts on alloxan-induced diabetic Rattus novergicus. J Med Plants Res 2011; 5(7): 1134-1139.
51. Martha T, Zainab MA, Khaled KA, Shaban LH, Muslim A. Antidiabetic and hypolipidaemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats. Int J Diab Met 2007; 15: 108-115.
52. Asaduzzaman M, Afiya A, Islam A, khan RI, Maruf A. Evaluation of antidiabetic, antihyperlipidemic and hepatoprotective effect of Allium sativum in alloxan induced diabetic rat. Bangladesh Pharmaceutical journal 2010; 13: 28-33.
53. Okoli CO, Ibiam AF, Ezike AC, Akah PA, Okoye TC. Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats. African Journal of Biotechnology 2010; 9(2): 248-259.
54. Dolores GM, Sevillano N, Salto R, Haidour A, Manzano M, Jimenez ML et al. Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: Role of mangiferin. Clinical Nutrition 2009; 1–10.
55. Ahmed A, Adeghate E, Sharma AK, Pallot DJ, Singh J. Effect of Momordica fruit juice on islet morphology in the pancreas of the streptozotocin diabetic rat. Diabetes Research and Clinical Practice 1998; 40: 145–151.
56. Mohammed A, Adelaiye AB, Bakari AG, Mabrouk MA. Anti-diabetic and some haematological effects of ethylacetate and n-butanol fractions of Ganoderma lucidum aqueous extract in alloxan induced diabetic wistar rats. Int J Med Medi Sci 2009; 1:530-535.
57. Witters LA (2001). The blooming of the French lilac. J Clin Invest 108:1105-1107.
444 Views | 812 Downloads
How to Cite
Gurjar HP, Irchhaiya DR, Vermas DA. REVIEW ON SOME MEDICINAL PLANTS WITH ANTIDIABETIC ACTIVITY. JDDT [Internet]. 14Mar.2016 [cited 4Dec.2021];6(2):45-1. Available from: