FORMULATION OF CLOTRIMAZOLE ORORETENTIVE JELLY

  • akshay sidharam javalgikar Sahyadri College of Pharmacy,Methwade

Abstract

ABSTRACT

 

Objective: Patient compliance and ease of administration are of significant importance in the design of dosage forms. Dysphasia is common among all age groups, especially in elderly and pediatrics. There are dosage forms like tablets, syrups in the market but still there is a need for new dosage form which acts effectively and locally. Jellies can provide an attractive alternative formulation in the treatment of oral candidiasis. So the present investigation aims to design, prepare and evaluate Clotrimazole jellies using xanthan gum with different concentrations. The benefits of these prepared jellies are increased bioavailability by-passing first pass metabolism. Method: The sucrose based jellies were prepared by heating and congealing method. Physical characteristics, pH, syneresis, in vitro dissolution testing, drug release kinetics, IR Spectral analysis and stability studies were conducted.

Result: The prepared formulations are free from gritty particles. Among the prepared formulations, formulation C3 containing 1.5% xanthan gum released 93.22% in 30min was found to be promising. Stability studies on the promising and other formulations indicated that there were no significant changes in the drug content and in vitro dissolution characteristics. IR spectroscopic studies indicated that there were no drug-excipient interactions. Anti-fungal studies revealed that there is no change in the molecular activity of the drug.

Conclusion: The prepared jellies of Clotrimazole could stay in the mouth for a longer period of time, which indicates a potential use of jellies of Clotrimazole for treating oral candidiasis.

Keywords: Clotrimazole; Jellies; Xanthan gum.

Keywords: Drug Delivery

Downloads

Download data is not yet available.

Author Biography

akshay sidharam javalgikar, Sahyadri College of Pharmacy,Methwade
Lecturer, Department of Pharmacology
Statistics
180 Views | 388 Downloads
How to Cite
1.
javalgikar akshay. FORMULATION OF CLOTRIMAZOLE ORORETENTIVE JELLY. JDDT [Internet]. 14Mar.2016 [cited 5Aug.2021];6(2):21-5. Available from: https://jddtonline.info/index.php/jddt/article/view/1180