IN VITRO EVALUATION OF CHEMICALLY DEACETYLATED XANTHAN GUM AS MATRIX POLYMER FOR CONTROLLED RELEASE TABLETS
The objective of the present investigation is to prepare Deacetylated Xanthan Gum, a new Xanthan Gum based polymer and to evaluate its application in controlled release (CR) and in the design of Simvastatin controlled release tablets. Deacetylated Xanthan Gum polymer was prepared by gelatinization of Xanthan Gum in the presence of sodium hydroxide. Matrix tablets each containing 40 mg of Simvastatin were formulated employing Deacetylated Xanthan Gum polymer in different proportions of drug and polymer and the tablets were evaluated. Simvastatin release from the formulated tablets was slow and spread over 12 hr and depended on percent polymer in the tablet. Release was diffusion controlled and followed zero order kinetics. Non â€“ Fickian diffusion was the drug release mechanism from the formulated tablets. Simvastatin release from matrix tablets F1 formulated employing 37 % Deacetylated Xanthan Gum was found suitable for the design of oral controlled release tablets.
Key-words: Deacetylated Xanthan Gum, Controlled release, Simvastatin, Matrix tablets.Â Â Â
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).