FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF DONEPEZIL HYDROCHLORIDE USING MODIFIED POLYSACCHARIDES
Abstract
ABSTRACT
The objective of the study was to prepare and evaluate orodispersible tablets of Donepezil Hydrochloride (DPH) using natural modified polysaccharides such as modified karaya gum and modified agar with glycine and mannitol. The prepared formulations were compared with Kyron T-314, super disintegrant, spray dried lactose, diluent for improvement in DT and other ODT parameters. FTIR studies revealed no interaction between DPH and excipients. Precompression parameters for all formulations were found to be satisfactory.
The oral dispersible tablets formulated using modified agar with glycine showed better disintegration time compared to modified karaya gum formulations. Different concentrations of mannitol and glycine were used in the formulation to study the improvement in the DT. The glycine formulations with modified agar gave better ODT parameters than modified karaya gum with mannitol and glycine formulations.
The optimized formulations of modified agar with glycine in different concentrations were prepared with spray dried lactose as diluent and compared with formulations of Kyron T-314 as superdisintegrant with spray dried lactose as diluent. The results of lactose and spray dried lactose as diluents in these formulations did not show any significant difference in ODT evaluation parameters. The formulations were optimized using ODT parameters such as disintegration time, wetting time, water absorption ratio and other physicochemical evaluation parameters. The accelerated stability studies of optimized formulation did not show significant changes compare to initial physicochemical evaluation parameters to conclude, modified polysaccharides with glycine can be used as superdisintegrant, which may be a cost effective alternative in comparison to synthetic superdisintegrant like Kyron T-314.
Keywords:
ODT, modified polysaccharides, kyron314, super disintegrantsDOI
https://doi.org/10.22270/jddt.v5i2.1092References
Chang R, Guo X, Burnside BA, Couch R. A review of fast dissolving tablets. Pharm tech. 2000;24(6):52-58
Biy X, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapidly disintegrating tablets prepared by direct compression method.Drugdev.ind.pharm. 1999;25(5):571-581
Gohel M, Patel M, Amin A, Agarwal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of Nimesulide using vacuum drying technique. AAPS pharm.sci.tech. 2004;5(3):1-6
Bhupendra G Prajapati, Nayan Ratnakar. A review on recent patents on fast dissolving drug delivery system. Pharm tech. 2009;1(3):790-798
Anupama kalia, Shelly Khurana, Neena bedi. Formulation and evaluation of mouth dissolving tablets of Oxcarbazepine. International journal of pharmacy and pharmaceutical sciences. 2009;1(1):12-23
Habib W, Khankari R, Hontz J. Fast-dissolving drug delivery systems: Critical review in therapeutics. Crit rev ther drug carrier syst. 2000;17(1):61-72
Biradar SS, Bhagavati ST, Kuppasad IJ. Fast dissolving drug delivery systems: A brief overview. The Int. J. Pharmacol. 2006;4(2):1531-2976
Vijay Sharma, Anil K, Philip, and Kamla Pathak Modified Polysaccharides as Fast Disintegrating Excipients for Orodispersible Tablets of Roxithromycin, AAPS.2008; 9(1):87-94
Published
Abstract Display: 766 
PDF Downloads: 1099 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.