COMPARISION OF POTENCY OF PANCURONIUM ,VECURONIUM AND ATRACURIUM AGAINST THE ACETYLCHOLINE INDUCED CONTRACTION ON ISOLATED FROG RECTUS ABDOMINIS MUSCLE
Objective : To compare potency Â Â ofÂ pancuronium , vecuroniumÂ Â Â Â andÂ atracuriumÂ Â against the acetylcholineÂ Â inducedÂ Â contraction onÂ Â isolatedÂ rectusÂ abdominis muscle of frog.
Material and Methods : In the present study Â theÂ neuromuscular blockingÂ effect ofÂ pancuronium, vecuronium andÂ atracurium was compared Â by using acetylcholine as Â standard on Â the height Â ofÂ Â frogÂ rectus abdominus muscleÂ contraction.
Results : Pancuronium , vecuronium and Â atracurium in the doses ofÂ 0.06 mg/lit, Â 0.12 mg/lit, Â 0.25 mg/lit Â producedÂ dose dependent Â Â reductionÂ in theÂ amplitudeÂ of
contractionÂ ofÂ acetylcholine Â (32Âµg,Â 64 Âµg ,Â 128 Âµg, 256Âµg, 512Âµg).
Conclusion : Among the three Â neuromuscular blockingÂ agents pancuronium Â appears equally potentÂ toÂ vecuronium as there is no statistically significant difference in half maximal inhibitory (IC50 ) values as compared toÂ half maximal inhibitory ( IC50 ) concentration value ofÂ atracurium.Keywords : Â Pancuronium, vecuronium, Â atracurium , Â non depolarizing blocking drugs
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