COMPARISION OF POTENCY OF PANCURONIUM ,VECURONIUM AND ATRACURIUM AGAINST THE ACETYLCHOLINE INDUCED CONTRACTION ON ISOLATED FROG RECTUS ABDOMINIS MUSCLE
Abstract
Objective : To compare potency   of pancuronium , vecuronium    and atracurium  against the acetylcholine  induced  contraction on  isolated rectus abdominis muscle of frog.
Material and Methods : In the present study  the neuromuscular blocking effect of pancuronium, vecuronium and atracurium was compared  by using acetylcholine as  standard on  the height  of  frog rectus abdominus muscle contraction.
Results : Pancuronium , vecuronium and  atracurium in the doses of 0.06 mg/lit,  0.12 mg/lit,  0.25 mg/lit  produced dose dependent   reduction in the amplitude of
contraction of acetylcholine  (32µg, 64 µg , 128 µg, 256µg, 512µg).
Conclusion : Among the three  neuromuscular blocking agents pancuronium  appears equally potent to vecuronium as there is no statistically significant difference in half maximal inhibitory (IC50 ) values as compared to half maximal inhibitory ( IC50 ) concentration value of atracurium.
Keywords : Â Pancuronium, vecuronium, Â atracurium , Â non depolarizing blocking drugsKeywords:
Pancuronium, vecuronium, atracurium, non depolarizing blocking drugsDOI
https://doi.org/10.22270/jddt.v5i2.1081References
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