COMPARISION OF POTENCY OF PANCURONIUM ,VECURONIUM AND ATRACURIUM AGAINST THE ACETYLCHOLINE INDUCED CONTRACTION ON ISOLATED FROG RECTUS ABDOMINIS MUSCLE

  • M Janardhan LBS college of pharmacy, Jaipur
  • G Kumar Anil Department of pharmacology, Kamineni Institute of Medical Sciences , Narketpally, Nalgonda Dist, Andhra Pradesh
  • T Kumar Naveen Department of pharmacology , Apollo Institute of Medical Sciences and Research, Hyderabad, Andhra Pradesh

Abstract

Objective : To compare potency   of  pancuronium , vecuronium     and  atracurium   against the acetylcholine   induced   contraction on   isolated  rectus  abdominis muscle of frog.

Material and Methods : In the present study  the  neuromuscular blocking  effect of  pancuronium, vecuronium and  atracurium was compared  by using acetylcholine as  standard on  the height  of   frog  rectus abdominus muscle  contraction.

Results : Pancuronium , vecuronium and  atracurium in the doses of  0.06 mg/lit,  0.12 mg/lit,  0.25 mg/lit  produced  dose dependent   reduction  in the  amplitude  of

contraction  of  acetylcholine  (32µg,  64 µg ,  128 µg, 256µg, 512µg).

Conclusion : Among the three  neuromuscular blocking  agents pancuronium  appears equally potent  to  vecuronium as there is no statistically significant difference in half maximal inhibitory (IC50 ) values as compared to  half maximal inhibitory ( IC50 ) concentration value of  atracurium.

Keywords :  Pancuronium, vecuronium,  atracurium ,  non depolarizing blocking drugs
Keywords: Pancuronium, vecuronium, atracurium, non depolarizing blocking drugs

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Author Biographies

M Janardhan, LBS college of pharmacy, Jaipur
LBS college of pharmacy, Jaipur
G Kumar Anil, Department of pharmacology, Kamineni Institute of Medical Sciences , Narketpally, Nalgonda Dist, Andhra Pradesh

Department of pharmacology,  Kamineni Institute of Medical Sciences , Narketpally, Nalgonda Dist,  Andhra Pradesh

T Kumar Naveen, Department of pharmacology , Apollo Institute of Medical Sciences and Research, Hyderabad, Andhra Pradesh

Department of pharmacology , Apollo Institute of Medical Sciences and Research, Hyderabad,  Andhra Pradesh

 

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Janardhan M, Anil G, Naveen T. COMPARISION OF POTENCY OF PANCURONIUM ,VECURONIUM AND ATRACURIUM AGAINST THE ACETYLCHOLINE INDUCED CONTRACTION ON ISOLATED FROG RECTUS ABDOMINIS MUSCLE. JDDT [Internet]. 13Mar.2015 [cited 22Sep.2021];5(2):65-8. Available from: https://jddtonline.info/index.php/jddt/article/view/1081