HEPATOPROTECTIVE ACTIVITY OF MAHONIA LESCHENAULTII TAKEDA. (ROOT WOOD AND ROOT BARK) ON COUNTRY MADE-LIQUOR (CML) INDUCED HEPATOTOXICITY IN RATS
The hepatoprotective potential of Mahonia leschenaultii Takeda. (root wood and root bark) extract was evaluated in Country-Made Liquor (CML)-induced hepatotoxicity in Wister rats. The rats were made hepatotoxic by administering (CML) (3 ml/100g body weight/day in two divided doses) and corn oil (1 ml/100g body weight /day in a single dose) orally for 21 days. The administration of root wood and root bark of Mahonia leschenaultii Takeda. extract (200 mg/kg body weight) mixed with tween 80 (0.5% w/w) orally from day 15 to day 21 along with CML. The different biochemical parameters tested are ALAT, ASAT, ALP, LDH, TGL, total protein, total cholesterol, Albumin, total bilirubin and direct bilirubin. The results were compared with standard drugs i.e. Silymarin (70 mg/kg body weight) orally. The histopathological study was carried out and histopathological changes were observed and compared. The study showed that the extract of root wood and root bark of Mahonia leschenaultii Takeda. is definitely a hepatoprotective agent and help in reduction of liver damage.
ÂKey words: Hepatoprotective, Mahonia leschenaultii Takeda. Country-Made Liquor, Root wood, and Root bark.
2. Dancygier H, Seitz HK, Mueller S, Alcoholic liver diseases, Springer, Berlin, Germany. 2010.
3. Shah CS, Qudry JS. A Text book of Pharmacognosy. 7th revised ed. Ahmedabad: B.S. Shah Prakashan; 1989-90, 1, 7.
4. Dhar ML, Dhawan BN, Prasad CR, Rastogi RP, Singh KK, Tandon JS, Screening of Indian Plants for Biological Activity, Indian J. Exp. Biol, 1974, 12(5) 125.
5. Fyson, PF, â€œThe Flora of the Nilgiris and Pulney Hill-topsâ€, M/S. Bishen Singh Mahendra Pal Singh, Dehradun and Periodical Experts, New Delhi, 1974, 13, 15.
6. Sastri BN, The Wealth of India, publication and Information Directorate (CSIR), 1962, 225-226.
7. Raghunathan K, Ramadas VNK, Tribal pockets of Nilgiiris, recordings of the field study on medicinal flora and health practices. Central Council for Research in Indian Medicine, 1978, 102,103.
8. Kokate CK, Practical Pharmacognosy. 4th ed. Delhi: Vallabh Prakashan; 1994, 149-150.
9. Rama Rao AVSS, Suryalakshmi A, A text book of biochemistry. New Delhi: C.B.S. Publication; 1996. 7, 449.
10. Reitman S, Frankel S, A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases, Amer. J. Clin. Pathol., 1957, 28(1), 56.
11. Kind PRN, King EJ, Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine, J. Clin. Path., 1954, 7, 322.
12. Stenley H, Organic Chemistry. New York: Mc Graw Hill Press; 1987. 5, 1097.
13. Wagner H, Bladt S. Drug Analysis, Springer-Verlag, Heidelberg, Berlin, 1996, 2, 42, 43.
14. Guligher AE, Kozloff EN. Essentials of Practical Micro technique. 2nd ed. Philadelphia: Lea and Febiger; 1971, 77.
15. Hawk PB, Oser BL, Summurson WH. Practical Physiological Chemistry. New York: Mc Graw Hill Press; 1954, 408.
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