IN-SILICO DOCKING INVESTIGATION, SYNTHESIS AND INVITRO ANTICANCER STUDY OF BENZOXAZOLE DERIVATIVES
Abstract
Benzoxazole derivatives display broad spectrum of biological and pharmacological activities. The main objective of the present study was to explore newer molecules with potent biological activity like anticancer activity. Insilico screening was done and compound with no violation in Lipinski rule of five and good docking score are selected for wet lab synthesize. Benzoxazole derivatives were synthesized and are evaluated for invitro anticancer studies. Â Derivatives were synthesized using different benzaldehyde and anhydride derivative. The synthesized compounds were then established on the basis of IR, MASS and 1H NMR spectral data and screened for anticancer activity on Human breast cancer cell line (MCF-7). The derivative showed significant activity on cell line.
Keywords: Benzoxazole, dihydrophthalazine, anticancer, MTT assay.
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DOI
https://doi.org/10.22270/jddt.v4i6.1014
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