Inhibition of Pro-Inflammatory Molecules by Ginger (Zingiber officinale Roscoe) and its Anti-Inflammatory Effects on Arthritis Patients

  • D Mutthuraj Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India
  • T Vinutha Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India
  • TS Gopenath Division of Biotechnology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India
  • B Kaginelli Division of Medical Physics, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India
  • M Karthikeyan Faculty of Medicine, Quest International University Perak, Malaysia
  • G Ashok Faculty of Medicine, Quest International University Perak, Malaysia
  • MS Ranjith Faculty of Medicine, Quest International University Perak, Malaysia
  • Pradeep Palanisamy Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia
  • Kanthesh M Basalingappa Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia

Abstract

Herbal medicinal plants are used to treat various disorders in many traditional medicinal systems around the world. Usage of this herb found in Indian and Chinese medicinal systems. The availability of ginger herb is Universal these days, where it is cultivated for its underground stem (Pseudo-stem). Most commonly used part is rhizome. This  ginger rhizome has many therapeutic uses including anti-inflammatory, anti-diabetics, antioxidant, anti-microbial and also curing in vomiting, constipation, indigestion, cold, fever,cough, nausea, reparatory conditions, bronchitis  etc., these activities were checked using different solvents of different polarity. Arthritis is known for its extreme joint pain and swelling may be treated by using ginger essential oil extract. It was studied that it has the capacity to reducing the pro-inflammatory molecules by lowering the RA-F, CRP, ESR level in the blood.The essences of ginger are due to the chemicals present in them. The products obtained from the ginger like essential oil and oleoresin are used all around the world for its food and pharmaceutical properties.The bioactive compounds like [6]- gingerol and its dehydrated form [6]- shogaol can inhibits the production of free radicals and oxidative stress, along with this properties it can reduce the pro-inflammatory molecules like prostaglandins by inhibiting COX-1 and COX-2.It also observed by the recent studies that the ginger and its extract have the capacity of suppressing the leukotriene biosynthesis by inhibiting 5-lipoxygenase. To this effect in-vitro study conducted in the lab shows the maximum inhibition as well as maximum protection by the ginger essential oil extract. The essential oil extraction were administered external apply and the variation in the certain proteins and inflammation related antibodies were studied.


Keywords:  Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, Shogaol, Auto-Immune Disorders.

Keywords: Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, Shogaol, Auto-Immune Disorders., Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, Shogaol

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Author Biographies

D Mutthuraj, Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

T Vinutha, Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

Division of Molecular Biology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

TS Gopenath, Division of Biotechnology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

Division of Biotechnology, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

B Kaginelli, Division of Medical Physics, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

Division of Medical Physics, Faculty of Life Sciences, JSS Academy of Higher Education and Research. (Deemed to be University), SS Nagara, Mysuru-570015, India

M Karthikeyan, Faculty of Medicine, Quest International University Perak, Malaysia

Faculty of Medicine, Quest International University Perak, Malaysia

G Ashok, Faculty of Medicine, Quest International University Perak, Malaysia

Faculty of Medicine, Quest International University Perak, Malaysia

MS Ranjith, Faculty of Medicine, Quest International University Perak, Malaysia

Faculty of Medicine, Quest International University Perak, Malaysia

Pradeep Palanisamy, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia

Kanthesh M Basalingappa, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia

Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), Malaysia

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Mutthuraj D, Vinutha T, Gopenath T, Kaginelli B, Karthikeyan M, Ashok G, Ranjith M, Palanisamy P, Basalingappa KM. Inhibition of Pro-Inflammatory Molecules by Ginger (Zingiber officinale Roscoe) and its Anti-Inflammatory Effects on Arthritis Patients. JDDT [Internet]. 15Apr.2020 [cited 16May2022];10(2-s):125-39. Available from: http://jddtonline.info/index.php/jddt/article/view/3963