Inhibition of Pro-Inflammatory Molecules by Ginger (Zingiber officinale Roscoe) and its Anti-Inflammatory Effects on Arthritis Patients
Abstract
Herbal medicinal plants are used to treat various disorders in many traditional medicinal systems around the world. Usage of this herb found in Indian and Chinese medicinal systems. The availability of ginger herb is Universal these days, where it is cultivated for its underground stem (Pseudo-stem). Most commonly used part is rhizome. This ginger rhizome has many therapeutic uses including anti-inflammatory, anti-diabetics, antioxidant, anti-microbial and also curing in vomiting, constipation, indigestion, cold, fever,cough, nausea, reparatory conditions, bronchitis etc., these activities were checked using different solvents of different polarity. Arthritis is known for its extreme joint pain and swelling may be treated by using ginger essential oil extract. It was studied that it has the capacity to reducing the pro-inflammatory molecules by lowering the RA-F, CRP, ESR level in the blood.The essences of ginger are due to the chemicals present in them. The products obtained from the ginger like essential oil and oleoresin are used all around the world for its food and pharmaceutical properties.The bioactive compounds like [6]- gingerol and its dehydrated form [6]- shogaol can inhibits the production of free radicals and oxidative stress, along with this properties it can reduce the pro-inflammatory molecules like prostaglandins by inhibiting COX-1 and COX-2.It also observed by the recent studies that the ginger and its extract have the capacity of suppressing the leukotriene biosynthesis by inhibiting 5-lipoxygenase. To this effect in-vitro study conducted in the lab shows the maximum inhibition as well as maximum protection by the ginger essential oil extract. The essential oil extraction were administered external apply and the variation in the certain proteins and inflammation related antibodies were studied.
Keywords: Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, Shogaol, Auto-Immune Disorders.
Keywords:
Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, Shogaol, Auto-Immune Disorders., Zingiber offcinale, Spice, Arthritis, Essential oil, Anti-Inflammatory, Gingerol, ShogaolDOI
https://doi.org/10.22270/jddt.v10i2-s.3963References
A.T. Mbaveng, V. Kuete, Zingiber officinale, Medicinal Spices and Vegetables from Africa, Therapeutic Potential against Metabolic, Inflammatory, Infectious and Systemic Diseases, 2017 Jan 14; 627-639. https://doi.org/10.1016/B978-0-12-809286-6.00030-3
Basil D. Roufogalis, Zingiber officinale (Ginger): A Future outlook on oits potential in prevention and treatment of diabetes and prediabetic states, New Journal of Science, 2014; 01-15. ID: 674684. https://dx.doi.org/10.1155/2014/674684
Laleh Khodaie, Omid Sadeghpoor, Ginger from Ancient Times to the new outlook, Jundishpaur Journal of Natural Pharmaceutical Products, 2015; 10(1): e18402. 01-05.
Jalal Bayati Zadeh, Nasriallah Moradi Kor, Phyiological and pharmaceutical effects of ginger (Zingiber officinale Roscoe) as a valuable medicinal plant, Pelagia Reasearch Library, European Journal of Experimental Biology, 2014; 4(1): 87-90.
Vikas Kumar, Sawinder Kaur, Radhika, Vyas G, Optimization of process for the preparation of antioxidant rich ginger candy by response surface methodology, International Food and Research Journal, 2017; 24(2):483-489.
Bhattarai S, Tran V. H, Duke C.C, The stability of gingerol and shogaol in aqueous solution, Journal of Pharmaceutical Science, 2001; 90:1658-1664.
Kumar G, Karthik L, Rao B, K. V, A review on pharmacological and phytochemical properties of Zingiber officinale Roscoe (Zingiberaceae), Journal of Pharmacy Research, 2011; 4(9):2963-2969.
Bhargava S, Dhabhai K, Batra A, Sharma A, Malhotra B, Zingiber officinale: Chemical and phytochemical screening and evaluation of its antimicrobial activities, Journal of Chemical and Pharmaceutical Research. 2012; 4(1):360-364.
Z. Kamaliroosta, L. Kamaliroosta, A.H. Elhamirad, Isolation and identification of ginger essential oil. Journal of Food Biosciences and Technology, 2013 July 10; 73-80.
Cragg G.M, Newman D.J, medicinal for the millennia. Annals of the NewYork Academy of sciences. 2001; 9(53):03-25.
Jyotsna Dhanik, Neelam Arya, Viveka Nand, A review on Zingiber officinale. Journal of Pharmacognosy and phytochemistry. 2017; 6(3):174-184.
Kottarapat Jeena, Vijayastelter B. Liju, Ramadasan Kuttan, Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian J Physiol Pharmacol. 2013; 57(1):51-62.
Julie L. Ryan, Gary R. Morrow, Ginger. Oncology nurse edition. 2010; 24(2):46-49.
Badreldin H. Ali, Gerald Blunden, Musbah O. Tanira, Abderrahim Nemmar, Some phytochemical, pharmacological and toxicological properties of ginger (Zinger officinale Roscoe): A review of recent research. Food and Chemical Toxicology. 2008; 46(2):409-420.
Brett White, MD. Ginger: An Overview. Complementary and alternative medicine, American Family Physician, 2007; 75:1689-91.
Z. Kamaliroosta, L. Kamaliroosta, A.H. Ethamirad, Isolation and Identification of Ginger Essential oil, Journal of Food Biosciences and Technology, 2013; 3:73-80.
Jolad S.D, Lantz R.C, Chen G.J, Bates R.B, Timmermann B.N, Commercially processed dry ginger (Zingiber offcinale): composition and effects on LPS- Stimulated PGE2 production. PhytoChemistry. 2005; 66(13):1614-35.
Humayun Riaz, Almas Begum, Syed Atif Raza, Zia Mohy-Ud-Din Khan, Hamad Yousaf, Ayesha Tariq, Antimicrobial peoperty and phytochemical study of ginger found in local area of Punjab, palistan. International Current Pharmaceutical Journal. 2015; 4(7): 405-409.
Z. N. Amiri, G.D. Najafpour, M. Mohammadi, A.A. Moghadamnia. Subcritical water extraction of bioactive compounds from ginger (Zingiber officinale Roscoe). International journal of engineering. 2018; 31(12):1991-2000.
V, Jyothiprabha, P. Venkatachalam. Preliminary phytochemical screening of different solvent extracts of selected Indian species. Int. J. Curr. Microbiol. Sci. 2016; 5(2):116-122.
Ammar Mohammad A.A, Mawahib ElAmin M.E, Sakina Mohamed Y. Total phenolic and flavonoid contents and antioxidant activity of ginger (Zingiber officinale Rosc.) rhizome, callus and callus treated with some elicitors. Journal of genetic engineering and biotechnology. 2018; 01-06. DOI: 10.1016/j.jgeb.2018.03.003
G.leelaprakash, s. Mohan Dass. Invitro anti-inflammatory activity of methanol extract of enicostemmaaxillare. International journal of drug development and research. 2010; 3(3):189-196.
Samy R.P, Ignacimuthu S, Antibacterial activity of some folklore medicinal plants used by tribals in Western Ghats in India, J of Ethnopharmacol, 2000; 69:63-71.
Rajendra V, Lakshmi K.S. In vitro and in-vivo anti-inflammatory activity of leaves of symplocos cochinchinensis (Lour) Moore ssp Laurina. Bangladesh J Pharmacol. 2008; 3: 121-124.
Samy R.P, Ignacimuthu S, Antibacterial activity of some folklore medicinal plants used by tribals in Western Ghats in India, J of Ethnopharmacol, 2000; 69:63-71.
Paini S.W, Tarsisius Dwi W.B, Fenny A.K, EvelynL.W. Difference of solvent polarity to phytochemical content and antioxidant activity of Plucheaindicia Less leaves extracts. International journal of pharmacognosy and phytochemical research. 2014; 6(4):850-855.
Rajendra V, Lakshmi K.S. In vitro and in-vivo anti-inflammatory activity of leaves of symplocos cochinchinensis (Lour) Moore ssp Laurina. Bangladesh J Pharmacol. 2008; 3:121-124.
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