Extraction and hepatoprotective activity of Pterospermum acerifolium on antitubercular drug induce toxicity in Swiss albino mice

  • Deepa Varandani College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India
  • Raghvendra Dubey College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India

Abstract

Present study deals with the extraction and hepatoprotective activity of Pterospermum acerifolium on antitubercular drug (Isoniazid and Rifampicin) induce toxicity in swiss albino mice. The leaves of Pterospermum acerifolium were subjected to maceration using hydro alcohol as solvent in the ratio 3:7 for 7 days. Toxicity study was performed on swiss albino mice at the different dose 1/20th, 1/10th and 1/5th   of 100, 200 and 400 mg/kg body weight. The effect of extract on biochemical parameters SGOT, SGPT, ALP and Bilirubin against isoniazid and rifampicin (INH+RIF) induced hepatotoxicity in mice was studied using distilled water as control and silymarin as standard. The biochemical studies were done span diagnostic kits. In animals treated with INH+RIF the level of SGOT, SGPT, ALP and Bilirubin was found to significantly high (P<0.05) as compared to vehicle treated group. In extract treated group level of SGOT, SGPT, ALP and Bilirubin was found to be significantly less (P<0.05) as compared to INH+RIF treated group. It can be concluded that hydroalcoholic extract of leaves of Pterospermum acerifolium possess significant heptoprotective potential against INH + RIF induced hepatotoxicity. The extract of leaves of Pterospermum acerifolium can be used in future in combination with antitubercular drug to prevent the acute hepatic damage produced on accidental over dosage.

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Author Biographies

Deepa Varandani, College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India

College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India

Raghvendra Dubey, College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India

College of Pharmacy, Dr. A. P. J. Abdul Kalam University, Indore (M.P.) India

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1.
Varandani D, Dubey R. Extraction and hepatoprotective activity of Pterospermum acerifolium on antitubercular drug induce toxicity in Swiss albino mice. JDDT [Internet]. 25Apr.2019 [cited 28Mar.2020];9(2-A):85-6. Available from: http://jddtonline.info/index.php/jddt/article/view/2787