Fabrication of Gelatin/Karaya gum blend microspheres for the controlled release of Distigmine bromide

  • O. Sreekanth Reddy Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India
  • M.C.S. Subha Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India
  • T. Jithendra Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India
  • C. Madhavi Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India
  • K. Chowdoji Rao Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Abstract

This paper reports the fabrication of gelatin/karaya gum microspheres by emulsion crosslinking method for controlled release of distigmine bromide. The microspheres were crosslinked with the help of glutaraldehyde and used for controlled oral delivery of distigmine bromide. The obtained microspheres were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Drug release kinetics of the microspheres is investigated in simulated intestinal fluid pH 7.4 at 37oC. Results illustrated that microspheres was influenced by the pH of test mediums, which might be suitable for intestinal drug delivery. The drug release kinetics was analyzed by evaluating the release data using different kinetic models.


Keywords: Karaya Gum, Gelatin, microspheres, drug delivery.

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Author Biographies

O. Sreekanth Reddy, Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

M.C.S. Subha, Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

T. Jithendra, Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

C. Madhavi, Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India

K. Chowdoji Rao, Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India

Department of Polymer Science and Technology, Sri Krishnadevaraya University, Ananthapuramu-515003, India

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How to Cite
Sreekanth Reddy, O., Subha, M., Jithendra, T., Madhavi, C., & Chowdoji Rao, K. (2019). Fabrication of Gelatin/Karaya gum blend microspheres for the controlled release of Distigmine bromide. Journal of Drug Delivery and Therapeutics, 9(3-s), 1-11. https://doi.org/10.22270/jddt.v9i3-s.2720