Formulation and characterization of sustained released tablet of deflazacort for colon targeting
Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant. Deflazacort are commonly Prescribed for the patient in disease condition such as Inflammatory Bowel Disease (IBD) ulcerative colitis (UC) and Crohn’s disease (CD). Delivery of drug substances to the ileo-colonic region may be an essential element of successful drug treatment (improved efficacy or reduced systemic toxicity) in topical treatment of the colon. The colon targeted drug delivery can also be used for effective treatment of diseases. This may improve efficacy of drug treatment, decrease in dose to be administered, improved drug utilization. It is a promising site for a drug which is unstable or poorly absorbed. Currently available formulation of deflazacort is conventional solid dosage form (6, 12, 18 & 30 mg tablets). Dosage form require frequent dose of administration due to its short half life of 1.1-1.9 hrs. So, present study is aimed to develop an colon targeted sustained release dosage form has been developed as these releases the drug slowly into the ileo- colonic region and maintain constant drug concentration in the serum for longer period of time.
Keywords: Deflazacort, Colon Targeting, IBD, Crohn’s Disease
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