EVALUATION AND QUALITY CONTROL OF NASAL SPRAY

  • Ramesh Shankarrao Kalkotwar Associate Prof. Dept. of QA, SND College of Pharmacy, Yeola, Nashik
  • Vidya V Bankar Patil Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Ankita Manibhai Patel Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Swati D. Tathe Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401
  • Swati S. Rawat Dept. of Pharmaceutics, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Abstract

Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals. This route is also advisable for drugs undergoing extensive first pass effect. The present article highlights the evaluation parameters of nasal spray, suspension, and solutions. While formulating the nasal drug delivery formulations various parameters are to be consider such as Appearance, Color, and Clarity, Identification, Drug content (Assay), Impurities and Degradation Products, Preservative(s) and Stabilizing Excipient(s) Assay, Pump Delivery, Spray content uniformity, Spray Content Uniformity (SCU) through Container Life, Spray Pattern and Plume Geometry, Droplet Size Distribution, Particle size distribution (suspension),  Microscopic Evaluation (Suspensions), Foreign Particulates,  Microbial limit,  Preservative Effectiveness, Net Content and Weight Loss (Stability), Leachables (Stability), PH, Osmolality.

 

Key words: Nasal spray, Evaluation, Quality control, Drug delivery system.

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Author Biographies

Ramesh Shankarrao Kalkotwar, Associate Prof. Dept. of QA, SND College of Pharmacy, Yeola, Nashik

Associate Professor,
Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401

India

Vidya V Bankar Patil, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401, INDIA

Ankita Manibhai Patel, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,

SND College of Pharmacy,

(Under Uni. of Pune)
Yeola, Dist Nashik 423 401, India

Swati D. Tathe, Dept. of Quality Assurance, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Student of PG,

Dept. of Quality Assurance,
SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401,India

Swati S. Rawat, Dept. of Pharmaceutics, SND College of Pharmacy, (Under Uni. of Pune) Yeola, Dist Nashik 423 401

Principal,

SND College of Pharmacy,
(Under Uni. of Pune)
Yeola, Dist Nashik 423 401

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How to Cite
1.
Kalkotwar R, Bankar Patil V, Patel A, Tathe S, Rawat S. EVALUATION AND QUALITY CONTROL OF NASAL SPRAY. JDDT [Internet]. 15Jul.2012 [cited 23Sep.2020];2(4). Available from: http://jddtonline.info/index.php/jddt/article/view/202