FORMULATION AND EVALUATION OF FLOATING TABLET FOR INDOMETHACIN
The present study was aimed to formulate and evaluate floating tablets of indomethacin by wet granulation method. Indomethacin is used as a potent anti-inflammatory drug with prompt anti pyretic action, mainly used for the treatment of osteoarthritis with half-life of 4.5 hrs. Indomethacin is stable in neutral or slightly acidic media. In this study, excipients like HPMC 5cps, sodium bi carbonate were incorporated in a nine different concentrations (F1-F9) along with other excipients (PVP K30, lactose, talc, and magnesium stearate) to formulate floating tablets by wet granulation method. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and stability studies. The dissolution profile of trial-6 (formulation 6) was observed to be better than other formulations. In trial-6 indomethacin was formulated as a floating tablet by using HPMC 5cps (120 mg) as a matrix forming polymer and sodium bi carbonate (40 mg) as a gas generating agent. Trial-6 formulation showed a good dissolution profile for a controlled period of time which was noticed to be as 97.78 % at the end of 12th hour. Thus, it can be concluded that the floating drug delivery system of indomethacin using the appropriate polymers in right amount may enhance the activity of the drug by prolonging the gastric residence time or reducing the floating lag time.
Keywords: Indomethacin, HPMC 5cps, Sodium bi carbonate.
2. Tripathi GK, Singh S. Formulation and In vitro evaluation of pH sensitive oil entrapped polymeric blended buoyant beads of Amoxicillin. Scholars Research Library. 2010; 2(2):31- 38.
3. Vedha H, Chaudhary J. The recent developments on gastric floating drug delivery system: An overview. Int j pharm tech res. 2010; 1(2):524-34.
4. Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A review. Int J Pharm Tech Res. 2009 Jul; 1(3):623-33.
5. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery systems: A Review.Journal of Pharmaceutical Science and Technology. 2011; 3(2):548-54.
6. Colombo P, Santi P, Bettini R, Brazel CS, Peppas NA. Drug release from swelling-controlled Systems. Handbook of pharmaceutical controlled release technology. 2000; 9:183-209.
7. Shruti S. A review on: recent advancement of stomach specific floating drug delivery system. International Journal of Pharmaceutical & Biological Archive. 2012; 2(6).
8. Nayak AK, Malakar J, Sen KK. Gastroretentive drug delivery technologies Current Approaches and future potential. Journal of Pharmaceutical Education and Research. 2010; 1(2):1.
9. Gupta P, Gnanarajan PK. Floating Drug Delivery System: A Review. International Journal of Pharma Research & Review. 2015; 4(8):37-44.
10. Kamalakkannan V, Puratchikody A, Prasanth VV, Masilamani K. Enhancement of Drugs Bioavailability by Floating Drug Delivery System-A Review. International Journal of Drug Delivery. 2011; 3(4):558.
11. Dubey J, Verma N. Floating drug delivery system: a review. International Journal of Pharmaceutical Sciences and Research. 2013; 4(8):2893.
12. Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A review. Int J Pharm Tech Res. 2009; (3):623-33.
13. Pare A, Yadav SK, Patil UK. Formulation and evaluation of effervescent floating tablet of Amlodipine besylate. Research journal of pharmacy and technology. 2008; 1(4):526-30.
14. El-Kamel AH, Sokar MS, Al Gamal SS, Naggar VF. Preparation and evaluation of ketoprofen floating oral delivery system. International journal of pharmaceutics.2001; 220(1):13-21.
15. Narang N. An updated review on: floating drug delivery system (FDDS). Int J App Pharm. 2011; 3(1):1-7.
16. Mathur P, Saroha K, Syan N, Verma S, Nanda S, Valecha V. An overview on recent Advancements and developments in gastroretentive buoyant drug delivery system. Der Pharmacia Sinica. 2011; 2(1):161-9.
17. Srikanth MV, Rao NS, Sunil SA, Ram BJ, Kolapalli VR. Statistical design and Evaluation of a propranolol HCl gastric floating tablet. Acta Pharmaceutica Sinica B. 2012; 2(1):60-9.
18. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug Delivery via gastric retention. Journal of Controlled release. 2000; 63(3):235-59.
19. Nama M, Gonugunta CS, Veerareddy PR. Formulation and evaluation of Gastroretentive Dosage forms of clarithromycin. AAPS PharmSciTech. 2008; 9(1):231
20. Gopalakrishnan S, Chenthilnathan A. Floating drug delivery systems: A Review. Journal of Pharmaceutical Science and Technology. 2011; 3(2):548-54.
21. Vedha H, Chaudhary J. The recent developments on gastric floating drug delivery system: An overview. Int j pharm tech res. 2010; 1(2):524-34.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).