AN ETHNO-PHARMACOLOGICAL EVALUATION OF CATUNAREGAM SPINOSA (THUMB.) TIRVENG FOR ANTIOXIDANT ACTIVITY
Abstract
Catunaregam spinosa (Thumb.) Tirveng have been reported in studies to possess antioxidant property. Therefore, present study was undertaken to validate different extracts of C. spinosa for antioxidant activity along with safety margin, according to OECD guidelines for toxicity. The extracts of different solvents, such as, distilled water, ethanol, methanol, acetone, chloroform; petroleum ether and benzene were subjected to phytochemical screening and characterization was done by using UV-Visible spectrophotometer. The toxicity studies displayed considerable margin of safety and no adverse effects observed upto 2gm/kg of administration of extract. The antioxidant property of extract of C. spinosa was evaluated for DPPH and FRAP activity. The IC50 value for DPPH activity was found to be 85% and the FRAP was found to be 2.5 μg/ml. These results when compared to standard values indicate towards superior antioxidant potential of C. spinosa extract.
DOI
https://doi.org/10.22270/jddt.v9i4-s.3189Published
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