AN ETHNO-PHARMACOLOGICAL EVALUATION OF CATUNAREGAM SPINOSA (THUMB.) TIRVENG FOR ANTIOXIDANT ACTIVITY
Catunaregam spinosa (Thumb.) Tirveng have been reported in studies to possess antioxidant property. Therefore, present study was undertaken to validate different extracts of C. spinosa for antioxidant activity along with safety margin, according to OECD guidelines for toxicity. The extracts of different solvents, such as, distilled water, ethanol, methanol, acetone, chloroform; petroleum ether and benzene were subjected to phytochemical screening and characterization was done by using UV-Visible spectrophotometer. The toxicity studies displayed considerable margin of safety and no adverse effects observed upto 2gm/kg of administration of extract. The antioxidant property of extract of C. spinosa was evaluated for DPPH and FRAP activity. The IC50 value for DPPH activity was found to be 85% and the FRAP was found to be 2.5 μg/ml. These results when compared to standard values indicate towards superior antioxidant potential of C. spinosa extract.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).