DEVELOPMENT AND IN VITRO EVALUATION OF AN ORAL FLOATING TABLET OF METRONIDAZOLE
Abstract
The present study was undertaken with an aim to develop and evaluate gastroretentive floating tablets of Metronidazole that are designed to retain in the stomach for a long time and have developed as a drug delivery system for better eradication of Helicobacter Pylori in peptic ulcer diseases. The floating tablets of Metronidazole were made by direct compression method using polymer Carbopol 934 and sodium bicarbonate and citric acid as gas generating agent. The tablets were evaluated by pre and post compression parameters such as weight variation, thickness, friability, hardness, drug content, in- vitro buoyancy studies and in-vitro dissolution studies and results were within the limits. Hardness was found to be in the range of 7.6 ± 0.27 kg/ cm² to 7.9 ± 0.35 kg/cm², the percent friability was in the range of 0.48% to 0.52% w/w and the tablets showed 94% to 97% uniformity in drug content. The in-vitro dissolution studies were carried out in a USP type- II apparatus in 0.1N HCl. The formulations were able to within 2-7 minutes and showed buoyancy >12 hrs. The drug-polymer ratio, viscosity grades of Carbopol 934 and gas generating agents were found to influence the release of drug and floating characteristics from the prepared floating drug delivery system of Metronidazole. Kinetically, among the 4 assessed models the release pattern of Metronidazole from the tablets fitted best to Higuchi’s and zero order indicated that diffusion is the predominant mechanism controlling the drug release.
Keywords: Metronidazole, Floating tablets, Carbopol 934, Gastroretentive, Dissolution
Downloads
References
2. Chein YW. Novel Drug Delivery Systems ed by Chein YW, Marcel Dekker, Inc., New York, USA 1992; 139-196.
3. Gurjar G., Bhowmick M., Rathi V., Rathi J. Design and evaluation of extended release cefuroxime axetil floating tablets with improved GI absorption. Journal of Drug Delivery and Therapeutics, 2017; 7(1):49-59. doi:10.22270/jddt.v7i1.1352
4. Keshari A., Tripathi D., Srivastava, A. Vishwas R. Formulation and evaluation of effervecent floating tablets of antidiabetic drug. Journal of Drug Delivery and Therapeutics, 2015; 5(6):43-55. doi:10.22270/jddt.v5i6.1176
5. Sahoo C., Rao S., Sudhakar M. Formulation and evaluation of controlled porosity osmotic pump tablets for zidovudine and lamivudine combination using fructose as osmogen. Journal of Drug Delivery and Therapeutics, 2017; 7(4):41-50. doi:10.22270/jddt.v7i4.1465
6. Momin S., Khan S., Ghadage D., Yadav A., Wagh A. Formulation and evaluation of bilayer tablets of propranolol hydrochloride. Journal of Drug Delivery and Therapeutics, 2017; 7(2):50-57. doi:10.22270/jddt.v7i2.1399
7. Amritha V., Kaur S , Pandey K, formulation and in vitro evaluation of floating tablets of hydroxypropylmethylcellulose K4M and carbopol using Metronidazole as model drug, International Journal of Pharmaceutical Science and Research, 2014; 2244-2249
8. Pant S, Badola A, Kothiyal P, A review on gastroretentive drug delivery system, Indian Journal of Pharmaceutical Science and Research. 2016; 4(2) :1-10
9. Dubey J, Verma N, Floating drug delivery system: A review, Indian Journal of Pharmaceutical Science and Research, 2013; 2893-2899
10. Yerikala R., Pudi V., Saravanakumar K., Vadhireddy S. Formulation and evaluation of floating drug delivery of cefotaxime using raft forming approach. Journal of Drug Delivery and Therapeutics, 2017; 7(4):110-119. doi:10.22270/jddt.v7i4.1473
11. Sharma A., Sharma P., Darwhekar G. Formulation and evaluation of bilayer tablet of metronidazole and dicyclomine hydrochloride for treatment of irritable bowel disease. Journal of Drug Delivery and Therapeutics, 2017; 7(7):56-58. doi:10.22270/jddt.v7i7.1586
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.