Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways

  • Gaurav Parihar IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Bhubharti Dehariya IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Santosh Ghule IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Pankaj Dixit IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012
  • Neelam Balekar IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Abstract

Quercetin is low molecular weight flavonoid having multiple neuropharmacological actions. Recently, its anticonvulsant effect was reported in rats using electrical kindling models. However, earlier cell culture studies have documented antagonistic action of quercetin on GABAA, GABAC and Glycine channels, which is contrary to recent findings. Hence, the present study aimed at characterizing the effects of quercetin administration in various experimental models of epilepsy. Dose-dependent effects of quercetin on maximal-electroshock seizure (MES) were determined. Further, the effective dose was tested in pentylenetetrazol-induced seizures (PTZ), and strychnine-induced seizures to study the involvement of GABA and Glycinergic receptors. The results revealed a potent anticonvulsant effect of quercetin in MES induced seizures at a dose of 5 and 10 mg/kg. This effect was found to be retained in case of PTZ-induced convulsions and strychnine-induced convulsions (quercetin 10 mg/kg). The present finding warrants further substantiation along with their correlation to molecular mechanism of action.

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Author Biographies

Gaurav Parihar, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Bhubharti Dehariya, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Santosh Ghule, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Pankaj Dixit, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

Neelam Balekar, IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

IPS Academy College of Pharmacy, Rajendranagar, A.B. Road, Indore, (M.P.) India – 452012

References

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How to Cite
Parihar, G., Dehariya, B., Ghule, S., Dixit, P., & Balekar, N. (2017). Quercetin Exerts Anti-convulsant Effects in Animal Model of Grand Mal Epilepsy: Modulation of GABA and Glycinergic Pathways. Journal of Drug Delivery and Therapeutics, 7(7), 194-196. https://doi.org/10.22270/jddt.v7i7.1633