A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS
Abstract
5-HT neurotransmission system is targeted by drugs useful in behavioural disorders, including anxiety, depression, psychosis and eating disorders. 5-HT1A autoreceptors, located on 5-HT neurones of the midbrain raphe nuclei, are coupled to K channels through a pertusis toxin-sensitive G-protein. 5-HT1A receptor agonists inhibit adenylyl cyclase, while 5-HT2C receptor agonists activate two signal transduction pathways coupled with these receptors. 5-HT1A and 5-HT2C receptors have lots potential in treating the disorders with less or no side effects.
Keywords: 5-HT1A, 5-HT2C, Receptor.Downloads
Download data is not yet available.
Statistics
266 Views | 366 Downloads
How to Cite
1.
Patil P, Chaudhari M, Sapkale P, Sarode S, Usman R. A REVIEW ON FUNCTIONAL COMPARISON OF 5-HT1A AND 5-HT2C RECEPTORS. JDDT [Internet]. 14Sep.2014 [cited 18May2024];4(5):55-7. Available from: https://jddtonline.info/index.php/jddt/article/view/975
Section
Review
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).