DESIGN AND EVALUATION OF POLYMERIC OCULAR DRUG DELIVERY SYSTEM FOR CONTROLLED DELIVERY OF CIPROFLOXACIN HYDROCHLORIDE
The field of Ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical scientist. The most frequently used dosage forms i.e. ophthalmic solutions and suspensions are compromised in their effectiveness by several limitations, leading poor ocular bioavailability. Ocuserts (or) Ophthalmic inserts are sterile preparations containing drug as dispersion or as solution in the polymeric support. Ocusert helps to improve ocular bioavailability by increasing the duration of contact with corneal tissue, thereby reducing the frequency of administration. Ciprofloxacin is a fluoroquinolone antibacterial drug effective in the treatment of bacterial conjunctivitis. The ciprofloxacin hydrochloride ocuserts were then evaluated for their physicochemical parameters like uniformity of thickness, weight, drug content and in vitro release pattern. It can be concluded that this ocular inserts formulation can be a promising for controlled release formulation.
Keywords: Ocusert, Ciprofloxacin hydrochloride, In vitro release pattern, controlled release.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).