A MULTIPURPOSE AND NOVEL CARRIER FOR DRUG DELIVERY AND TARGETING - VIROSOMES
There is presently passionate investigation bustle aimed at the improvement of new delivery systems for vaccines. The aspiration is to identify best possible methods for presenting target antigens to the immune system in a manner that will elicit immune responses appropriate for protection against, or treatment of, a specific disease. Virosomes are biocompatible, biodegradable, nontoxic, and non-autoimmunogenic, attempts have been made to use them as vaccines or adjuvant as well as delivery systems for drugs, nucleic acids, or genes for therapeutic purposes. Influenza virus is the most common virus of choice. There are at present numerous factors that are creating pressure to develop delivery systems for vaccines. First, in the existing regulatory milieu, there is a budding prerequisite to build up vaccines that are very well defined in molecular requisites. Unambiguous targeting and liberation as well as the display of antigens on the surface of Professional antigen-presenting cells (APCs) are key issues in the blueprint and improvement of new-generation vaccines intended at the initiation of both humoral and cell mediated immunity. Prophylactic vaccination in opposition to infectious diseases in general aims at the generation of humoral immune responses to prevent infection. However, mmunization with live vaccines bears the peril of causing ailment. For that reason, unconventional vaccine delivery systems are must to produce better immune response. Virosomal technology presents a fresh urbane delivery system to congregate these challenges. On the whole, virosomes guard pharmaceutically active substances from proteolytic dilapidation and low pH within endosomes, allowing their contents to linger intact when they get in touch with the cytoplasm. This is a foremost benefit of virosomal transporter systems over other drug-delivery vehicles, including liposomal and proteoliposomal carrier systems.Â
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).