Development and In-Vitro Evaluation of Itraconazole Loaded Nanoemulsion

  • Ashish Kumar Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India
  • Ajay Kumar Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India https://orcid.org/0000-0002-5597-1336
  • Abhishek Soni School of Pharmacy Abhilashi University Chail chowk Mandi HP, India
  • Jyoti Devi Research Scholar of Pharmaceutics Himalayan College of Pharmacy Kala Amb Sirmour HP, India

Abstract

Nanoemulsions are one of the major popular formulation systems in the pharmaceutical and cosmeceutical fields. Nanoemulsions are generally composed of a dispersed oil phase within a continuous aqueous phase. Itraconazole is an antifungal medication used to treat a number of fungal infections. It is in the triazole family of medications. Itraconazole, antifungal agent has poor bioavailability due to low aqueos solubility.  In this research preformulation study, Fourier transform infrared (FTIR) analysis studies was conducted for studying the compatibility. In preparation of Itraconazole loaded nanoemulsions from the ternary phase diagram ratio of surfactant to co-surfactant (Smix) was optimized with broad area. Optimized surfactant and co surfactant are accurately weighed and then vortexed for 5-10 min for Smix preparation. Particle size and value of PDI was found to be 159.21nm and zeta potential demonstrated the stability of prepared nanoparticles was found to be -15.9mv .Transmission electron microscope indicated a homogeneous distribution of small, spherical optimized Itraconazole loaded nanoemulsion formulation. These studies were aimed to improve the oral bioavailability of Itraconazole through nanoemulsions.


Keywords: Nanoemulsion, Itraconazole, Surfactant, cosurfactant, Nanoparticles

Keywords: Nanoemulsion, Itraconazole, Surfactant, cosurfactant, Nanoparticles, Nanoemulsion, Itraconazole, Surfactant, cosurfactant, Nanoparticles

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Author Biographies

Ashish Kumar, Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India

Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India

Ajay Kumar, Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India

Department of Pharmaceutics, School of Pharmacy, Arni University, Kathgargh Distt. Kangra (H.P.), India

Abhishek Soni, School of Pharmacy Abhilashi University Chail chowk Mandi HP, India

School of Pharmacy Abhilashi University Chail chowk Mandi HP, India

Jyoti Devi, Research Scholar of Pharmaceutics Himalayan College of Pharmacy Kala Amb Sirmour HP, India

Research Scholar of Pharmaceutics Himalayan College of Pharmacy Kala Amb Sirmour HP, India

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1.
Kumar A, Kumar A, Soni A, Devi J. Development and In-Vitro Evaluation of Itraconazole Loaded Nanoemulsion. JDDT [Internet]. 15May2022 [cited 8Dec.2022];12(3):31-2. Available from: http://jddtonline.info/index.php/jddt/article/view/5317