Curative impacts of Ethanoic Extract of Laportea aestuans (L) Chew in Aspirin-Induced Ulcerative compromise in Male Rats
Abstract
Toxicity of Non-steroidal anti-inflammatory drugs (NSAIDs) are being reported with its diverse effect in the host resulting in ulcerations. Ulceration was induced orally using aspirin. Twenty-four male Wistar rats were used for this study (120-150g). Rats were divided into 6 groups with each group containing 4 rats. Rats were pre-treated orally with cimetidine, a reference drug. Group 1 rats orally received 1% gum acacia solution as the control group, Group 2 rats orally administered 25 mg/kg aspirin and served as the ulcerated, untreated group, rats in groups 3 and 4 were pre-treated orally with 200 mg/kg and 400 mg/kg respectively for 3 days while rats in groups 5 and 6 were pre-treated orally with 50 mg/kg cimetidine and 50 mg/kg catechin respectively for 3 days. The result of this study shows that the ulcerated, untreated rats showed increased concentrations of The result of this study shows that the ulcerated, untreated rats showed increased concentrations of acid output, pepsin activity with a concomitant decrease in pH values, and mucin content compared to control group but pre-treatment with different doses, cimetidine and catechin reversed these observations. Activities of superoxide oxidase were decreased in the ulcerated, untreated group with a concomitant increase in lipid peroxidation concentration but pre-treatment with different doses, cimetidine and catechin reversed these observations. In conclusion, the ethanoic extract of L. aestuans can be said to be used therapeutically agaisnt aspirin-induced gastric ulcer which is due to the presence of bioactive compounds in the plant.
as an anti-ulcerogenic agent against aspirin-induced gastric ulcer which is due to the presence of phytochemicals in the plant.
Keywords: Ulcerations, bioactive compounds, oxidative stress, superoxide dismutase, aspirin
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