Profile of Bioactive Phyto-compounds in Essential Oil of Cymbopogon martinii from Palani Hills, Western Ghats, INDIA
Abstract
Worldwide interest in use of plants based natural products (PBNPs) has been growing, and its beneficial effects being rediscovered for the development of novel drugs. Literature survey on indigenous traditional knowledge bestows ethnopharmacological potentials of PBNPs that has inspired current research in drug design and discovery; PBNPs provide baseline for the development of novel drug leads against various pharmacological targets. Studies indicate that Cymbopogon martini Essential Oil (CMEO) exhibit wide range of biological activities such as hepatoprotective, antifungal, insecticide, antioxidant and antibacterial. Pharmacological properties in Palmarosa Essential Oil (PEO) may be due to the presence of compounds like 4-Decen-6-yne, (Z), 2-Ethylimino-4-methyl-pent-3-enenitrile, Dihydrocarvyl acetate, 2-Methylbenzaldehyde, Geranyl butyrate, 1,5,9,9-Tetramethyl-1,4,7-cycloundecatriene. However, its application is limited because of the odor, color and taste. In the present study, GCMS based profile of bioactive phyto-compounds in essential oil of Cymbopogon martinii along with its physiochemical, biological, molecular, pharmacological and drugable properties has been envisaged.
Keywords: Cymbopogon martinii Essential Oil (CMEO); Pharmacological Activity; ADMET Properties; Bioactive Compounds; Plant Based Natural Products (PBNPs);
Keywords:
Cymbopogon martinii Essential Oil (CMEO), Pharmacological Activity, ADMET Properties, Bioactive Compounds, Plant Based Natural Products (PBNPs)
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References
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2. Avoseh O, Oyedeji O, Rungqu P, Nkeh-Chungag B, Oyedeji A. Cymbopogon species; ethnopharmacology, phytochemistry and the pharmacological importance. Molecules. 2015; 20(5):7438-53. https://doi.org/10.3390/molecules20057438
3. Prashar A, Hili P, Veness RG, Evans CS. Antimicrobial action of palmarosa oil (Cymbopogon martinii) on Saccharomyces cerevisiae. Phytochemistry. 2003; 63(5):569-75. https://doi.org/10.1016/S0031-9422(03)00226-7
4. Raina VK, Srivastava SK, Aggarwal KK, Syamasundar KV, Khanuja SP. Essential oil composition of Cymbopogon martinii from different places in India. Flavour and Fragrance Journal. 2003; 18(4):312-5. https://doi.org/10.1002/ffj.1222
5. Kumar R, Srivastava M, Dubey NK. Evaluation of Cymbopogon martinii oil extract for control of postharvest insect deterioration in cereals and legumes. Journal of food protection. 2007; 70(1):172-8. https://doi.org/10.4315/0362-028X-70.1.172
6. Kalagatur NK, Nirmal Ghosh OS, Sundararaj N, Mudili V. Antifungal activity of chitosan nanoparticles encapsulated with Cymbopogon martinii essential oil on plant pathogenic fungi Fusarium graminearum. Frontiers in pharmacology. 2018; 9:610. https://doi.org/10.3389/fphar.2018.00610
7. Mishra PK, Kedia A, Dubey NK. Chemically characterized Cymbopogon martinii (Roxb.) Wats. essential oil for shelf life enhancer of herbal raw materials based on antifungal, antiaflatoxigenic, antioxidant activity and favorable safety profile. Plant Biosyst. 2015; 150:1313-1322. https://doi.org/10.1080/11263504.2015.1054450
8. Caballero-Gallardo K, Olivero-Verbel J, Stashenko EE. Repellency and toxicity of essential oils from Cymbopogon martinii, Cymbopogon flexuosus and Lippia origanoides cultivated in Colombia against Tribolium castaneum. Journal of Stored Products Research. 2012; 50:62-5. https://doi.org/10.1016/j.jspr.2012.05.002
9. Andrade BF, Conti BJ, Santiago KB, Fernandes A, Sforcin JM. C ymbopogon martinii essential oil and geraniol at non-cytotoxic concentrations exerted immunomodulatory/anti-inflammatory effects in human monocytes. Journal of Pharmacy and Pharmacology. 2014; 66(10):1491-6. https://doi.org/10.1111/jphp.12278
10. Al-Shalah LA, Hindi NK, Mohsen IH. Essential Oils. Essential Oils: Bioactive Compounds, New Perspectives and Applications. 2020; 9:29.
11. Chávez-González ML, Rodríguez-Herrera R, Aguilar CN. Essential oils: A natural alternative to combat antibiotics resistance. Antibiotic Resistance-Mechanisms and New Antimicrobial Approaches; Kon, K., Rai, M., Eds. 2016; 227-37. https://doi.org/10.1016/B978-0-12-803642-6.00011-3
12. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology advances. 2015; 33(8):1582-614. https://doi.org/10.1016/j.biotechadv.2015.08.001
13. Rašković A, Milanović I, Pavlović N, Ćebović T, Vukmirović S, Mikov M. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC complementary and alternative medicine. 2014; 14(1):1-9. https://doi.org/10.1186/1472-6882-14-225
14. Khan MS, Ahmad I. In vitro antifungal, anti-elastase and anti-keratinase activity of essential oils of Cinnamomum-, Syzygium- and Cymbopogon-species against Aspergillus fumigates and Trichophyto rubrum. Phytomedicine. 2011; 19:48-55 https://doi.org/10.1016/j.phymed.2011.07.005
15. Yoon MY, Cha B, Kim JC Recent trends in studies on botanical fungicides in agriculture. The plant pathology journal. 2013; 29(1):1. https://doi.org/10.5423/PPJ.RW.05.2012.0072
16. Matthew KM. Flora of the Tamilnadu Carnatic. The Rapinat Herbarium, St. Joseph's College, Tiruchirapalli, India; 1981
17. Gamble JS, Fischer CE. Flora of the Presidency of Madras. London, UK: West, Newman and Adlard; 1915. https://doi.org/10.5962/bhl.title.21628
18. Eleyinmi AF Chemical composition and antibacterial of Gongronema latifolium J Zhejiang Univ Sci B 2007; 8:352-358 https://doi.org/10.1631/jzus.2007.B0352
19. Zhou Y, Wu F, Li L, Shen X, Chen G, Wang X, Liang X, Tan M, Huang Z. Computational approaches in preclinical studies on drug discovery and development. Frontiers in Chemistry. 2020; 8:726-31. https://doi.org/10.3389/fchem.2020.00726
20. Ramya S, Neethirajan K, Jayakumararaj R. Profile of bioactive compounds in Syzygium cumini-a review. Journal of Pharmacy research. 2012; 5(8):4548-53.
21. Gaba J, Bhardwaj G, Sharma A. Lemongrass. In Antioxidants in Vegetables and Nuts-Properties and Health Benefits 2020 (pp. 75-103). Springer, Singapore. https://doi.org/10.1007/978-981-15-7470-2_4
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Soorya C, Balamurugan S, Basha AN, Kandeepan C, Ramya S, Jayakumararaj R. Profile of Bioactive Phyto-compounds in Essential Oil of Cymbopogon martinii from Palani Hills, Western Ghats, INDIA. JDDT [Internet]. 15Jul.2021 [cited 20May2024];11(4):60-5. Available from: https://jddtonline.info/index.php/jddt/article/view/4887
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