Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation

  • Vandana Gupta Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India https://orcid.org/0000-0002-2543-5911
  • Ashish Manigauha Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India https://orcid.org/0000-0003-4122-2999

Abstract

The purpose of present exploration was to modify kappa (k)-Carrageenan, by crosslinking, and assessed it as a tablet disintegrant to strengthen the solubility of the drug (aceclofenac) in tablet formulation. Modified k-Carrageenan was synthesized by reacting it with epichlorhydrin at heterogenous  conditions. The swelling action of the product was investigated in order to optimize reaction circumstances for chemical cross-linking. Best modified k-Carrageenan procured by optimizing the reaction conditions and it was characterized for swelling index, particle size distribution, solubility, viscosity, gel strength and Fourier transform infrared spectroscopy (FTIR). Influence of modified k-Carrageenan on dissolution profile of therapeutic was also investigated along with other evaluation parameters. Modified k-Carrageenan exhibiting significant swelling index which is comparable to that of superdisintegrants. On comparative investigation as a tablet disintegrant by preparing anhydrous dicalcium phosphate tablet, modified k-Carrageenan showed disintegration time less than 20 seconds. Dissolution of aceclofenac (Class II) tablet formulaion utilizing modified k-Carrageenan was comparable with commercially available superdisintegrants. Faster dissolution of the accommodated drug was achieved with modified k-Carrageenan which was comparable with dissolution of the tablet formulation containing other superdisintegrants. The competent concentration of k-Carrageenan was found to be 5-15% as tablet disintegrant. Modified k-Carrageenan might be encouraging tablet disintegrant in fast dissolving formulations and can be worn in direct compression method.


Keywords: k-Carageenan. Epichlorhydrin. Aceclofenac. Crosslinking. Superdisintegrant

Keywords: k-Carageenan, Epichlorhydrin, Aceclofenac, Crosslinking, Superdisintegrant

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Author Biographies

Vandana Gupta, Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India

Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India

Ashish Manigauha, Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India

Mittal Institute of Pharmacy, Opposite Bhopal Memorial Hospital & Research Centre, Ayodhya Bypass Road, Navi Bagh, Karond, Bhopal-462038, M.P., India

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Gupta V, Manigauha A. Modification of natural hydrocolloid as disintegrant in aceclofenac tablet formulation. JDDT [Internet]. 15Mar.2021 [cited 20Apr.2021];11(2):42-0. Available from: http://jddtonline.info/index.php/jddt/article/view/4586