Simultaneous Estimation and Validation of Artemether and Lumefantrine by UV Spectrophotometry in Tablet

  • Megha Mishra Department of Pharmacy, Barkatullah University, Bhopal MP India
  • Anand Mundada Department of Pharmacy, Barkatullah University, Bhopal MP India

Abstract

A UV spectrophotometric method has been developed for the simultaneous determination of Artemether and Lumefantrine. The spectroscopic method for estimation of Artemether and Lumefantrine employed Area under curve method for analysis using Ethanol as solvent. Artemether has absorbance maxima 253.2 nm and Lumefantrine has absorbance maxima 235.2 nm and both these drugs obey Beer's law in concentration range of 4.24 -67.84 μg/ml for Artemether and 4.68 -28.08 μg/ml for Lumefantrine. The recovery studies ascertained the accuracy of the purposed method and the results were validated as per ICH guidelines. The results were found satisfactory and reproducible. The method was applied successfully for the estimation of Artemether and Lumefantrine in tablet dosage form without the interference of common excipients.


Keywords: Artemether, Lumefantrine; Area under curve; Simultaneous; Estimation

Keywords: Artemether, Lumefantrine; Area under curve; Simultaneous; Estimation, Artemether, Lumefantrinem, Area under curve, Simultaneous, Estimation

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Author Biographies

Megha Mishra, Department of Pharmacy, Barkatullah University, Bhopal MP India

Department of Pharmacy, Barkatullah University, Bhopal MP India

Anand Mundada, Department of Pharmacy, Barkatullah University, Bhopal MP India

Department of Pharmacy, Barkatullah University, Bhopal MP India

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Mishra M, Mundada A. Simultaneous Estimation and Validation of Artemether and Lumefantrine by UV Spectrophotometry in Tablet. JDDT [Internet]. 15Mar.2021 [cited 20Apr.2021];11(2):16-2. Available from: http://jddtonline.info/index.php/jddt/article/view/4576