Evaluation of the Antioxidant Activity of Some Plants Used in the Management of Erectile Dysfunction by the BWA Community in Mali
Abstract
The erection has always symbolized strength and virile health. Erectile dysfunction is undoubtedly a concern as old as humanity. Tamarindus indica L., Guiera senegalensis J.F.Gmel and Ximenia americana L. are commonly used in the traditional treatment of erectile dysfunction by the Bwa community in Mali. The aim of this study was to measure the total polyphenols and flavonoids and then to evaluate the antiradical activity of the extracts (aqueous and hydroalcoholic macerated and decocted) of the organs of these species. The study found that for all species, the hydro-alcoholic macerated extract showed the best results. The polyphenol contents have been 36.85±0.21 mgGAE/g; 32.60±0.25 mgGAE/g and 29.79±0.51 mgGAE/g for Ximenia americana, Tamarindus indica and Guiera senegalensis respectively. The flavonoid contents have been 22.03±0.15 mgQE/g; 17.53±0.02 mgQE/g and 8.03±0.03 mgQE/g for Ximenia americana, Tamarindus indica and Guiera senegalensis respectively. The antiradical activity expressed in IC50 is 37.54±0.75 µg/mL; 52.75±0.71 µg/mL and 54.66±1.14 µg/mL for Ximenia americana, Tamarindus indica and Guiera senegalensis respectively. This study revealed that those plants are rich in total polyphenols and show a good antiradical activity. This wealth would justify their traditional use. The biological tests would be necessary to confirm their use in the treatment of erectile dysfunction.
Keywords: Erectile dysfunction, polyphenols, antioxidant activity, Bwatun-Mali.
Keywords:
Erectile dysfunction, polyphenols, antioxidant activity, Bwatun-Mali
Downloads
Download data is not yet available.
References
1. Sharma M., Arya D., Bhagour K., and Gupta R. S. Natural aphrodisiac and fertility enhancement measures in males. A review. Current Medicine Research and Practice 2017; 7:51–58.
2. Bivalacqua TJ, Usta MF, Kendirci M. and Pradhan L. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. The Journal of Sexual medicine, 2005; 2(2):187- 198.
3. Esper R J, Nordaby RA, Vilarino J O, Paragano A, Cacharron J L. and Machado R. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol, 2006; 5(1):4.
4. Kuhn J. M. Hypogonadisme et dysfonction érectile. Act méd Int. 2001; 5(6):256- 262.
5. Hafez E. S and Hafez S. D. 2005. Erectile dysfunction: anatomical parameters, etiology, diagnosis, and therapy. Archives of Andrology, 51: 15-31.
6. Lue T. F. Erectile dysfunction. The New England Journal of Medecine, 2000; 342:1802-1813.
7. Carpentier M., Sahpaz S. et Bailleul F.: Plantes et dysfonction érectile. Phytothérapie. 2004 ; 2(3):66–71. https://doi.org/10.1007/s10298-004-0024-3.
8. Morabandza C.J., Ondele R., Elion Itou R.D.G., Etou Ossibi A.W., Imbiella C., Mokondjimobe E., Ongoka P. R. and Abena A. A. Aphrodisiac activity of aqueous and hydro ethanolic extracts of the stem bark of strychnos camptoneura (longaniaceae) in wistar rat. Asian Journal of Science and Technology, 2017; 08(10):6055-6059.
9. Togola I, Dembélé J, Daou C, Dénou A, Diarra N, Badiaga M, Konare MA, Karembé M, Sanogo R. Ethnobotanical Survey and Phytochemical Screening of Some Plants used in the Management of Erectile Dysfunction in Bwatun (Mali). Journal of Natural Product and Plant Resources, 2020; 9(1):1-8.
10. Drewes SE, Georges J. and Khan F. R. Recent findings on natural products with erectile dysfunction activity. Phytochemistry, 2003; 62:1019-1025.
11. Andzouana M. and Mombouli J.B. Assessment of the Chemical and Phytochemical Constituents of the Leaves of a Wild Vegetable Ochthocharis dicellandroides (Gilg). 2012.
12. Boua B. B., Mamyrbekova-Bekro J. A., Kouamé B. A., Bekro Y. A. Criblage phytochimique et potentiel érectile de Turraea heterophylla de Côte d’Ivoire. Journal of Applied Biosciences 2013; 68:5394-5403.
13. Dey L.M., Anoja S., Attele D. and Chun-Sun Y.M. 2002. Alternative therapy for type 2 diabetes. Alternative Medecine Review 2002; 7(1):45-58.
14. Keïta JN, Traore N, Diarra N, Koné D, Mariko B, Pelcouliba D. and Poisson JF. Isolation and Identification of Nicotiflorin from the Leaves of Costus spectabilis (Fenzl) K. Schum. Der Chemica Sinica 2019; 10(1):782-787.
15. Singleton, V. L.; Orthofer, R.; Lamuela-Raventos, R. M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu Reagent. Methods Enzymol. 1999; 299:152-178.
16. Togola I, Dembélé AA, Tounkara F, Diarra N, Konaré MA, Karembé M, Maiga SZ, Dembélé D. Evaluation of in vitro Antioxidant Activities of Ethanol Extracts of Datura innoxia Mill. Leaves and Seeds Harvested in Mali. Annual Research and Review in Biology 2019; 33(2):1–8.
17. Chang C, Yang M, Wen H, Chern J. 2002. Estimation of total flavonoids content in propolis by two complementary colorimetric methods. J Food Drug Analysis. 10: 178-182.
18. Traoré K., Haidara M., Dénou A., Kanadjigui F., Sogoba M.N., Diarra B., Maïga S. et Sanogo R. Criblage phytochimique et activités biologiques de quatre plantes utilisées au Mali dans la prise en charge du paludisme chez les enfants. European Scientific Journal, 2019; 15(6):212-226.
19. Brand Williams W, Cuvelier ME, Berset C. Use of free radical method to evaluate anti-oxidant activity. Lebensmittel Wissenschaft and Technologie. 1995; 28(1):25-30.
20. Mariko M., Sarr S.O., Diop A., Modi I. A., Dackouo B., Diop Y. M. Antioxidant activity study and total phenolic determination of leaf extracts of Ximenia americana L. (Olacaceae) an antitumor plant used traditionally in Mali. Journal of Applied Biosciences, 2016; 106:10258-10265.
21. Nurhanani R., Sarni M. J., Amirah F. A. M., Senthilkumar S., Azlina A. A. 2012. Effects of various solvents on the extraction of antioxidant phenolics from the leaves, seeds, veins and skins of Tamarindus indica L. Food Chemistry 2012; 131:441–448.
22. Abubakr M, Sirag N, Osman I, Osman M, Abakar S and Aboul-Enein AM. Anticancer and antioxidant activities of Guiera senegalensis. Sudan JMS 2013; 8(3).
23. Kabran G. R. M., Ambeu N. C., Mamyrbékova-Békro J. A. ; Békro Y. A. Phenols et flavonoïdes totaux dans les extraits organiques de dix Plantes utilisées dans la traditherapie du cancer du sein en Côte d’Ivoire. European Journal of Scientific Research, 2012; 68(2):182-190.
24. Ahodegnon D. K., Gnansounou M., Bogninou R. G. S., Kanfon E. R., Chabi B et al., Biochemical profile and antioxidant activity of Parkia biglobosa and Tamarindus indica fruits acclimated in Benin. Int. J. Adv. R es. 2018; 6(11):702-711.
25. Maikai, V. A., Kobo, P. I. and Maikai, B. V. O. Antioxidant properties of Ximenia Americana. African Journal of Biotechnology, 2010; 9(45):7744-7746.
26. Kouamé, J. C. G., Palé E., Bassolé H., Guissou I. P., Simporé J., Nikiéma J. B. Etude des propriétés cytotoxiques et anti-radicalaires d’extraits de feuilles et de galles de Guiera senegalensis J. F. Gmel (Combretacae). Science et technique, Sciences de la santé, 2009.
27. Talbi H., Boumaza A., Karym. E. M., Talbi J., Hilali A. Evaluation de l’activité antioxydante et la composition physico-chimique des extraits méthanolique et aqueux de la Nigella sativa L. Journal of Materials and Environmental Science 2015; 6(4):1111-1117.
28. Saleem A., Ahotupa M. and Pihlaja K. Total phenolics concentration and antioxidant properties of extracts of medicinal plants of Pakistan. Zeitschrift Naturforschung 2001; 56(11-12):973-978.
29. Gauthaman K. and Adaikan P. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction: an evaluation using primates, rabbit and rat, Phytomedicine, 2008; 15(1-2):44–54. doi: 10.1016/j.phymed.2007.11.011.
2. Bivalacqua TJ, Usta MF, Kendirci M. and Pradhan L. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. The Journal of Sexual medicine, 2005; 2(2):187- 198.
3. Esper R J, Nordaby RA, Vilarino J O, Paragano A, Cacharron J L. and Machado R. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol, 2006; 5(1):4.
4. Kuhn J. M. Hypogonadisme et dysfonction érectile. Act méd Int. 2001; 5(6):256- 262.
5. Hafez E. S and Hafez S. D. 2005. Erectile dysfunction: anatomical parameters, etiology, diagnosis, and therapy. Archives of Andrology, 51: 15-31.
6. Lue T. F. Erectile dysfunction. The New England Journal of Medecine, 2000; 342:1802-1813.
7. Carpentier M., Sahpaz S. et Bailleul F.: Plantes et dysfonction érectile. Phytothérapie. 2004 ; 2(3):66–71. https://doi.org/10.1007/s10298-004-0024-3.
8. Morabandza C.J., Ondele R., Elion Itou R.D.G., Etou Ossibi A.W., Imbiella C., Mokondjimobe E., Ongoka P. R. and Abena A. A. Aphrodisiac activity of aqueous and hydro ethanolic extracts of the stem bark of strychnos camptoneura (longaniaceae) in wistar rat. Asian Journal of Science and Technology, 2017; 08(10):6055-6059.
9. Togola I, Dembélé J, Daou C, Dénou A, Diarra N, Badiaga M, Konare MA, Karembé M, Sanogo R. Ethnobotanical Survey and Phytochemical Screening of Some Plants used in the Management of Erectile Dysfunction in Bwatun (Mali). Journal of Natural Product and Plant Resources, 2020; 9(1):1-8.
10. Drewes SE, Georges J. and Khan F. R. Recent findings on natural products with erectile dysfunction activity. Phytochemistry, 2003; 62:1019-1025.
11. Andzouana M. and Mombouli J.B. Assessment of the Chemical and Phytochemical Constituents of the Leaves of a Wild Vegetable Ochthocharis dicellandroides (Gilg). 2012.
12. Boua B. B., Mamyrbekova-Bekro J. A., Kouamé B. A., Bekro Y. A. Criblage phytochimique et potentiel érectile de Turraea heterophylla de Côte d’Ivoire. Journal of Applied Biosciences 2013; 68:5394-5403.
13. Dey L.M., Anoja S., Attele D. and Chun-Sun Y.M. 2002. Alternative therapy for type 2 diabetes. Alternative Medecine Review 2002; 7(1):45-58.
14. Keïta JN, Traore N, Diarra N, Koné D, Mariko B, Pelcouliba D. and Poisson JF. Isolation and Identification of Nicotiflorin from the Leaves of Costus spectabilis (Fenzl) K. Schum. Der Chemica Sinica 2019; 10(1):782-787.
15. Singleton, V. L.; Orthofer, R.; Lamuela-Raventos, R. M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu Reagent. Methods Enzymol. 1999; 299:152-178.
16. Togola I, Dembélé AA, Tounkara F, Diarra N, Konaré MA, Karembé M, Maiga SZ, Dembélé D. Evaluation of in vitro Antioxidant Activities of Ethanol Extracts of Datura innoxia Mill. Leaves and Seeds Harvested in Mali. Annual Research and Review in Biology 2019; 33(2):1–8.
17. Chang C, Yang M, Wen H, Chern J. 2002. Estimation of total flavonoids content in propolis by two complementary colorimetric methods. J Food Drug Analysis. 10: 178-182.
18. Traoré K., Haidara M., Dénou A., Kanadjigui F., Sogoba M.N., Diarra B., Maïga S. et Sanogo R. Criblage phytochimique et activités biologiques de quatre plantes utilisées au Mali dans la prise en charge du paludisme chez les enfants. European Scientific Journal, 2019; 15(6):212-226.
19. Brand Williams W, Cuvelier ME, Berset C. Use of free radical method to evaluate anti-oxidant activity. Lebensmittel Wissenschaft and Technologie. 1995; 28(1):25-30.
20. Mariko M., Sarr S.O., Diop A., Modi I. A., Dackouo B., Diop Y. M. Antioxidant activity study and total phenolic determination of leaf extracts of Ximenia americana L. (Olacaceae) an antitumor plant used traditionally in Mali. Journal of Applied Biosciences, 2016; 106:10258-10265.
21. Nurhanani R., Sarni M. J., Amirah F. A. M., Senthilkumar S., Azlina A. A. 2012. Effects of various solvents on the extraction of antioxidant phenolics from the leaves, seeds, veins and skins of Tamarindus indica L. Food Chemistry 2012; 131:441–448.
22. Abubakr M, Sirag N, Osman I, Osman M, Abakar S and Aboul-Enein AM. Anticancer and antioxidant activities of Guiera senegalensis. Sudan JMS 2013; 8(3).
23. Kabran G. R. M., Ambeu N. C., Mamyrbékova-Békro J. A. ; Békro Y. A. Phenols et flavonoïdes totaux dans les extraits organiques de dix Plantes utilisées dans la traditherapie du cancer du sein en Côte d’Ivoire. European Journal of Scientific Research, 2012; 68(2):182-190.
24. Ahodegnon D. K., Gnansounou M., Bogninou R. G. S., Kanfon E. R., Chabi B et al., Biochemical profile and antioxidant activity of Parkia biglobosa and Tamarindus indica fruits acclimated in Benin. Int. J. Adv. R es. 2018; 6(11):702-711.
25. Maikai, V. A., Kobo, P. I. and Maikai, B. V. O. Antioxidant properties of Ximenia Americana. African Journal of Biotechnology, 2010; 9(45):7744-7746.
26. Kouamé, J. C. G., Palé E., Bassolé H., Guissou I. P., Simporé J., Nikiéma J. B. Etude des propriétés cytotoxiques et anti-radicalaires d’extraits de feuilles et de galles de Guiera senegalensis J. F. Gmel (Combretacae). Science et technique, Sciences de la santé, 2009.
27. Talbi H., Boumaza A., Karym. E. M., Talbi J., Hilali A. Evaluation de l’activité antioxydante et la composition physico-chimique des extraits méthanolique et aqueux de la Nigella sativa L. Journal of Materials and Environmental Science 2015; 6(4):1111-1117.
28. Saleem A., Ahotupa M. and Pihlaja K. Total phenolics concentration and antioxidant properties of extracts of medicinal plants of Pakistan. Zeitschrift Naturforschung 2001; 56(11-12):973-978.
29. Gauthaman K. and Adaikan P. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction: an evaluation using primates, rabbit and rat, Phytomedicine, 2008; 15(1-2):44–54. doi: 10.1016/j.phymed.2007.11.011.
Crossmark
Statistics
401 Views | 49 Downloads
How to Cite
1.
Togola I, Dembélé J, Daou C, Diarra N, Konaré MA, Sanogo R. Evaluation of the Antioxidant Activity of Some Plants Used in the Management of Erectile Dysfunction by the BWA Community in Mali. JDDT [Internet]. 15Nov.2020 [cited 17Apr.2024];10(6):57-1. Available from: https://jddtonline.info/index.php/jddt/article/view/4559
Section
Research
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.