EVALUATION OF ANTI-INFLAMMATORY ACTIVITY ON VITEX NEGUNDO LINN.

  • Saravana K Kumar Sree Vidyanikethan Collage of Pharmacy, Tirupati, Chittoor Dist., Andhra Pradesh, India.
  • P Nagaveni Oil Technological Research Institute, JNTUA Anantapur 515 001, Andhra Pradesh, India.
  • K Anitha Sree Vidyanikethan Collage of Pharmacy, Tirupati, Chittoor Dist., Andhra Pradesh, India.
  • Subahan TM Mahaboob Sri Krishna Chaithanya College of Pharmacy, Madanapalle,Chittoor, Andhra Pradesh, India.

Abstract

The anti-inflammatory activity of Vitex Negundo Linn was studied in carrageenan induced paw edema & cotton pellet granuloma in albino rats. The anti-inflammatory activity of the Ethanolic and aqueous extracts (100 & 200mg/kg) were evaluated against the carrageenan induced paw edema of rats were compared with the standard drug Indomethacin. The extract at the test doses of 100 and 200 mg/kg body weight reduced the paw edema induced by Carrageenan by 48.13% and 57.18% respectively, where as the standard drug showed 61.16. The paw edema suppressant effect was significant (P < 0.05) in the dose of 100&200 mg/kg ethanol and aqueous extracts. When compared between control and two extracts, Ethanolic extract shows maximum anti-inflammatory activity. Thus it can be concluded that the extract of Vittex Negundo.Linn extract posses the anti-inflammatory activity. 

Keywords: Anti-inflammatory activity, Vittex Negundo, paw edema, ethanolic extract, Cotton pellet granuloma.

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Kumar, S., Nagaveni, P., Anitha, K., & Mahaboob, S. (2013). EVALUATION OF ANTI-INFLAMMATORY ACTIVITY ON VITEX NEGUNDO LINN. Journal of Drug Delivery and Therapeutics, 3(2). https://doi.org/10.22270/jddt.v3i2.451