Formulation and Evaluation of Novel Formulation for Diabetes Induced Hypertension using Modified Innate Superdisintegrant

  • Vinay Pandit Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India
  • Dipanker Kashive Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India
  • Tarun Kumar Sharma Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Abstract

Objectives: Diabetes is a chronic disease and is a group of metabolic disorders characterized by high levels of sugar in blood (hyperglycemia). Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in patients with diabetes. The objective of this research is to formulate Fast dissolving tablets of Pioglitazone and Cilnidipine for the effective treatment of diabetes induced hypertension.


Methods: Six formulations were prepared by direct compression technique by using Opuntia ficus-indica as an innate superdisintegrant.


Result and Discussion: All the formulations were subjected for precomprression, post compression parameters and shows all the data within the specific limits. F5 formulation with the mixture of polymers viz. Opuntia ficus indica, SSG, croscarmellose sodium, magnesium stearate, DiCOM showed comparatively fast disintegration and best release of drug than that of all other formulation. The tablets of F5 formulation disintegrated within 18.53 seconds can provide fast relief in the body. The in-vitro dissolution results revealed that the drug release of F5 formulation tablets was more than 90% for Pioglitazone and near to 70% for Cilnidipine within 30 minutes. Stability studies were performed on F5 formulation tablets showed no significant changes in color, disintegration time and in-vitro dissolution which showed that appearance of tablets was having no effect.


Conclusion: Fast dissolving tablets of Pioglitazone and Cilnidipine can be successfully prepared using direct compression technique and it will enhance the drug dissolution, which will further increase absorption and bioavailability of both drugs.


Keywords: Pioglitazone, Cilnidipine, diabetes induced hypertension, fast dissolving tablets, direct compression.

Keywords: Pioglitazone, Cilnidipine, diabetes induced hypertension, fast dissolving tablets, direct compression

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Author Biographies

Vinay Pandit, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Dipanker Kashive, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Tarun Kumar Sharma, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P, India

References

1. Kaveeshwar AS, Cornwall J, the current state of diabetes mellitus in India, Australas Med J. 2014; 7(1):45–48.
2. Geldsetzer P, Manne-Goehler J, Theilmann M, Davies JI, Awasthi A, Vollmer S, Jaacks LM, Bärnighausen T, Atun R Diabetes and Hypertension in India: A Nationally Representative Study of 1.3 Million Adults. JAMA Intern Med. 2018; 178(3):363-372.
3. Mattson JS, Cerutis DR, Diabetes mellitus: a review of the literature and dental implications, Compend Contin Educ Dent. 2001; 22(9):757-60, 762, 764.
4. https://en.wikipedia.org/wiki/Pioglitazone.
5. https://en.wikipedia.org/wiki/Cilnidipine.
6. Masih A, Kumar A, Singh S, Tiwari A, Fast dissolving tablets: A review, School of pharmaceutical sciences, Jaipur National University, Jaipur, Rajasthan, 2017; 9(2).
7. Siddiqui N, Garg G, Sharma P, “Fast dissolving tablets: preparation, charcaterisation and evaluation: an overview.” Int J. Pharm.Sci. Res. 2010; 4(2):87-95
8. Hugo J, Nutritional composition of the Prickly pear (Opuntia ficus-indica), Nutritional composition of fruit cultivars, Academic Press, 691-712.
9. Ahad H.A, Sreenivasulu R, Reddy B, Kavitha K, Sumapadmaja B, Isolation and Characterization of Ficus indica fruit mucilage, Journal of Pharmacy Research, 2011; 4(3):726-727.
10. Pavia D.L, Gary M.L, James A, George S. Ultraviolet spectroscopy, Introduction to spectroscopy, 4th ed. Cengage learning; 2009. P. 381-417.
11. Safila N, Zehra A, Tasleem M, Assay of Pioglitazone HCl by using UV Visible spectrophotometer, British Journal of Research.
12. Sharma Y.R, Introduction to UV Visible spectroscopy. Elemental organic spectroscopy. 4th ed. S. Chand Publisher; 1980. P. 69-190.
13. Ashford M. Assessment of biopharmaceutical properties. In: Aulton ME. Aulton’s pharmaceutics the design and manufacture of medicines. 3rd ed. London. Harcourt Publishers Limited; 2007. P. 304-322.
14. Patel A, Panchal A, Patel V, Nagar A. “FTIR spectroscopic method for quantitative analysis of Cilnidipine in tablet dosage form” International Journal Of Pharma Sciences and Research, 2015; 4(6).
15. Farouk F, Moussa BA, Azzazy H.M.E. Fourier transform infrared spectroscopy for in process inspection, counterfeit detection and quality control of anti- diabetic drugs. Spectroscopy 2011; 26:297-309.
16. Lima de Assis A.C, Alves L, Malheiro J, Barros A.R.A, Opuntia ficus-indica L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization, Polymers 2019; 11:1124.
17. Lachman L, Liberman HA and Kang JL. The theory and practice of industrial pharmacy. 3rded. Mumbai: Varghese publication house; 1986. P. 293-345.
18. Mohamed EA, Hammid SNA. Formulation and evaluation Pioglitazone tablets. Int. J. PharmSci.2013; 2(2):339-346.
19. Sharma D, Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders, International Scholarly Research Notices , 2013: 8.
20. Venkateswarlu K, Jami KP. Formulation development and in vitro evaluation of mouth dissolving tablets of Pioglitazone hydrochloride; Pharma Tutor. 2016; 4(12):37-42.
21. Mohan A, Gundamaraju R, In vitro and in vivo evaluation of fast-dissolving tablets containing solid dispersion of lamotrigine, Int J Pharm Investig. 2015; 5(1):57–64.
22. Prashant, A.B., Taware, G.V., Hariprasanna, R.C., and Najmuddin, M. Development and evaluation of mucoadhesive buccal tablets of loratadine. Journal of Pharmacy Research, 2011; 4:2699-2702.
23. Siepmann F, Mathematical modeling of drug dissolution, International Journal of Pharmaceutics, 2013; 453(1):12-24.
24. Shaikh H.K, Kshirsagar R.V, Pati S.G, Mathematical Models For Drug Release Characterization: A Review, World journal of pharmacy and pharmaceutical sciences 2014; 3(5):472-80.
25. Patel Z.K, Patel M, Patel R.R, A Review: Formulation of Fast Dissolving Tablet, Pharmatutor Magazine; 2(3):1-17.
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Pandit V, Kashive D, Sharma T. Formulation and Evaluation of Novel Formulation for Diabetes Induced Hypertension using Modified Innate Superdisintegrant. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):240-5. Available from: http://jddtonline.info/index.php/jddt/article/view/4412