Development and Characterization of Barbaloin Gel for the Safe and Effective Treatment of Psoriasis

  • Navdeep Singh Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Kamya Goyal Department of pharmaceutical Analysis and Chemistry, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Shivi Sondhi Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India
  • Shammy Jindal Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Abstract

Psoriasis is an inflammatory skin disease which cause inflammation to the skin and generally the symptoms includes white or red colour of irregular skin; the patches are developed and they are commonly itchy and scaly to the skin. Barbaloin is an herbal phytoconstituent which is obtained from the plant aloe vera leaf part. In the present study hydrogels formulation batches from F1 to F10 were prepared by using carbopol 934, Xanthan gum, carbopol 940, and carbopol 71G NF as a gelling agent. The prepared formulations from F1 to F10 were evaluated for their physical appearance, Grittiness, spreadability, Homogeneity, viscosity, pH, swelling index and microscopical evaluation. The changes in each evaluation parameter were examined at multiples concentration of each polymer. The effects of gelling agent in each formulation were observed and it will help us to justify the suitable range of polymer as a single or in combination with other gelling agent. From these studies it was found to be formulation F2, F4, F7 and F10 showing good gelling properties and further these four formulations are selected for In Vitro drug release studies. By In Vitro drug release kinetics study formulation F2 and F10 showed higher release as compared to F4 and F7. Furthermore, formulation F2 and F7 had good kinetic release study and showed non fickian drug release as the n value was between 0.8-0.9. Therefore, from the above release study parameters formulation F2 and F10 show the best optimized release characterstics as compare to the selected optimized formulations F4 and F7.


Keywords: Psoriasis, Barbaloin, Hydrogel, Formulation and Evaluation.

Keywords: Psoriasis, Barbaloin, Hydrogel, Formulation and Evaluation

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Author Biographies

Navdeep Singh, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Kamya Goyal, Department of pharmaceutical Analysis and Chemistry, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of pharmaceutical Analysis and Chemistry, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Shivi Sondhi, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Shammy Jindal, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalamukhi, Himachal Pradesh 176031, India

Research scholar, Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Sector-125, Noida 201303, India

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Singh N, Goyal K, Sondhi S, Jindal S. Development and Characterization of Barbaloin Gel for the Safe and Effective Treatment of Psoriasis. JDDT [Internet]. 15Sep.2020 [cited 25Sep.2020];10(5):188-97. Available from: http://jddtonline.info/index.php/jddt/article/view/4299