Antioxidant and Antimicrobial Activities of Methanolic Leaves Extract of Lagerstroemia parviflora

Authors

  • Namita Bharadwaj Associate Professor, Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India
  • Anjna Chaturvedi Research Scholar Ph.D., Chemistry Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India

Abstract

An antioxidant is a molecule capable of terminating the chain reactions that damage cells by removing free radical intermediates and inhibit other oxidation reactions by thereby reducing stress responsible for many degenerative disorders. The present study was concerned with phytochemical screening, antioxidant, antimicrobial activities of methanolic leaves extract of Lagerstroemia parviflora. It was observed that the methanol extract showed IC 50 value of 76.05µg/ml as compare to standard ascorbic acid 14.66 µg/ml. It was evident that the extracts showed proton-donating ability and this could serve as free radical inhibitors or scavengers, acting possibly as primary antioxidants. Thus the methanol extract of this plant possesses the strongest ability to scavenge DPPH radical. The leaves extracts of Lagerstroemia parviflora exhibited potential antibacterial activity against Staphylococcus aureus (20±0.2, 21±0.1 and 23±0.1), Salmonella bongori (9±0.3, 12±0.1and 15±0.5) and Aspergillus niger (7±0.1, 9±0.1 and 11±0.2) at the concentration level of 25-100mg/ml. The Results of antimicrobial activity of extract showd more effectiveness against both the selected bacteria (Staphylococcus aureus and Salmonella bongori) found less effective against fungus (Aspergillus niger). The present study suggests that the use of leaves of this plant may be exploited for health supplements and has potential for topical treatment.

Keywords: Lagerstroemia parviflora, Antioxidant, Antimicrobial

Keywords:

Lagerstroemia parviflora, Antioxidant, Antimicrobial

DOI

https://doi.org/10.22270/jddt.v10i3-s.4174

Author Biographies

Namita Bharadwaj, Associate Professor, Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India

Associate Professor, Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India

Anjna Chaturvedi, Research Scholar Ph.D., Chemistry Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India

Research Scholar Ph.D., Chemistry Dr. C. V. Raman University, Kota Bilaspur, (C.G.), India

References

Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sökmen A, Akpulat H, Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae), Journal of Ethnopharmacology, 2003; 87:215-220.

Zhu KX, Lian CX, Guo XN, Peng W, Zhou HM, Antioxidant activities and total phenolic contents of various extracts from defatted wheat germ, Food Chemistry, 2011; 126:1122-1126.

Spacil Z, Novakova L, Solich P, Analysis of phenolic compounds by high performance liquid chromatography and ultra-performance liquid chromatography, Talanta, 2008; 76:189-199.

Haila K, Effects of carotenoids and carotenoid-tocopherol interaction on lipid oxidation in vitro, Thesis, University of Helsinki, Helsinki, 1999.

Fukumoto LR, Mazza,Assessing G, antioxidant and prooxidant activities of phenolic compounds,Journal of Agricultural and Food Chemistry, 2000; 48:3597-35604.

Kitts DD, An evaluation of the multiple effects of the antioxidant vitamins, Trends in Food Science & Technology, 1997; 8:198-203

Wall J, Antioxidants in prevention ofreperfusion damage of vascularendothelium,Pharmacology, 2000; 1:67-71.

Aquino R, Morelli S, Tomaino A, Pellegrino M, Saija A, Grumetto L, Puglia C, Ventura D, Bonina F, Grumetto L, Antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H. B. K. Leaves and their major flavonoids, Journal of Ethnopharmacology, 2002; 79:183- 191.

Silva BA, Malva JO, Dias ACP, St. John’s Wort (Hypericum perforatum) extracts and isolated phenolic compounds are effective antioxidants in several in vitro models of oxidative stress, Food Chemistry, 2008; 110:611-619.

Ito N, Fukushina S, Tsuda H, Carcinogenicity and modification of the carcinogenic response by BHA, BHT and other antioxidants, CRC Critical Review in Toxicology, 1985; 15:109-115.

Canadanovic-Brunet JM, Djilas DM, Cetkovic GS, Tumbas VT, Mandić AI, Canadanovic VM, Antioxidant activities of different Teucrium montanum L. extracts,International Journal of Food Science & Technology, 2006; 41:667-673.

Djilas SM, Canadanovic-Brunet JM, Cetkovic GS, Tumbas VT, Antioxidative activity of some herbs and species - review of ESR studies, In P. S. Gill, A. M. Webb, G. A. RutledgeEds., Magnetic resonance in Food Science, Belton, Cambridge, 2003, pp. 110-120.

ANostro N, Germano MP, D′Angelo V, Marino A, Cannetelli MA, Extraction methods and bioautography for evaluetion of medicinal plant antimicrobial activity, Letters in Applied Microbiology, 2000; 30:379-384.

Marimuthu P, Wu CL, Chang HT, Chang ST, Antioxidant activity of the ethanolic extract from the bark of Chamaecyparisobtusa var. Formosana, Journal of the Science of Food and Agriculture, 2008; 88:1400-1405.

Proestos C, Boziaris IS, Nychas GJE, Komaitis M, Analysis of flavonoids and phenolic acids in Greek aromatic plants: Investigation of their antioxidant capacity and antimicrobial activity, Food Chemistry, 2006; 95:664- 671.

Papadopoulou C, Soulti K, Roussis IG, Potential antimicrobial activity of red and white wine phenolic extracts against strains of Staphylococcus aureus, Escherichia coli and Candida albicans,Food Technology and Biotechnology, 2005; 43:41-46.

Obame LC, Koudou J, Kumulungui BS, Bassolé IHN, Edou P, Ouattara AS, Traoré AS, Antioxidant and antimicrobial activities of Canarium schweinfurthii Engl. Essential oil from Centrafrican Republic, African Journal of Biotechnology, 2007; 6:2319-2323.

Basile A, Sorbo S, Spadaro V, Bruno M, Maggio A, Faraone N, Rosselli S, Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae), Molecules, 2009; 14:939-952.

Saddiqe Z, Naeem I, Maimoona A, A review of the antibacterial activity of Hypericum perforatum L, Journal of Ethnopharmacology, 2010; 131:511-521.

Recio MC, RíosJL, Villar A, A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotheraphy Research, 1989; 3:117-125.

Rauha JP, Remes S, Heinonen M, Hopia A, Kahkonen M, KujalaT, Vuorela KPH, Vuorela P, Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds, International Journal of Food Microbiology, 2000; 56:3-12.

Bisignano G, Tomaino A, Lo Cascio R, Crisafi G, Uccella N, Saija A, On the in vitro antimicrobial activity of oleuropein and hydroxytyrosol, Journal of Pharmacy and Pharmacology, 1999; 51:971-974.

Chan MMY, Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin, Biochemical Pharmacology, 2002; 63:99-104.

Wen AM, Delaquis P, Stanich K, Toivonen P, Antilisterial activity of selected phenolic acids, Food Microbiology, 2003; 20:305-311.

Date AA, Naik B, Nagarsenker MS. Novel drug delivery systems: potential in improving topical delivery of anti-acne agent. Skin Pharmacol Physiol. 2006; 19:2-16.

Collier CN, Harper JC, Cafardi JA. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. 2008; 58:56-59.

Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, Shalita AR, Thiboutot D. Management of acne: a report from a global alliance to improve outcomes in Acne. J Am Acad Dermatol. 2003; 49:S1-S37.

Gollnick H., Cunliffe W., Berson D., Dreno B.A., Leyden J., Shalita A. and Thiboutot D. Finlay Management of Acne: A Report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2003; 49:S1-S37.

Krautheim A. and Gollnick H. Transdermal penetration of topical drugs used in the treatment of acne. Clin Pharmacokinet. 2003; 42:1287-1304.

Date A.A., Naik B. and Nagarsenkar M.S. Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne agents. Skin Pharmacol Physiol. 2006; 19:2-16.

Schofer T., Nienhaus A., Vieluf D., Berger J. and Ring J.: Epidemiology of Acne in the General Population: The Risk of Smoking. Br J Dermatol. 2001; 145:100-104.

Bassett IB, Pannowitz DL, Barnetson RSC. A comparative study of teatree oil versus benzoyl peroxide in the treatment of acne. Med J Aus.1990; 153:455-458.

Olufunmiso, Olajuyigbe, O. and Afolayan, Anthony, J. Phenolic Content and antioxidant property of the bark extract of Ziziphus mucronata wild. Subsp. Mucronata wild, BMC, Complementary and alternative medicine. 2011; 11:130.

Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-496.

Published

2020-07-14
Statistics
Abstract Display: 543
PDF Downloads: 662

How to Cite

1.
Bharadwaj N, Chaturvedi A. Antioxidant and Antimicrobial Activities of Methanolic Leaves Extract of Lagerstroemia parviflora. J. Drug Delivery Ther. [Internet]. 2020 Jul. 14 [cited 2026 Feb. 15];10(3-s):206-10. Available from: https://jddtonline.info/index.php/jddt/article/view/4174

How to Cite

1.
Bharadwaj N, Chaturvedi A. Antioxidant and Antimicrobial Activities of Methanolic Leaves Extract of Lagerstroemia parviflora. J. Drug Delivery Ther. [Internet]. 2020 Jul. 14 [cited 2026 Feb. 15];10(3-s):206-10. Available from: https://jddtonline.info/index.php/jddt/article/view/4174