Development of Transdermal Patches for the Delivery of Chlorpheniramine in Infants using Hypromellose and Cassava Starch Composite Polymers
Background: Chlorpheniramine is an antihistamine that is used in the treatment of rhinitis and other allergies. Objectives: The objectives of this research was to develop and evaluate transdermal patches for improved delivery of chlorpheniramine in infants using hypromellose and cassava starch composite polymers. Methods: Chlorpheniramine transdermal patches were formulated by solvent casting method using varying amounts of hypromellose (hydroxypropyl methylcellulose), cassava starch and polyethylene glycol 4000. The formulated transdermal patches were characterized by Fourier Transform Infra-red Spectroscopy (FT-IR), folding endurance, elongation breaking test, percentage moisture uptake/loss and ex vivo permeation studies. Results: The spectra showed no chemical interaction between the ingredients. The transdermal patches showed elastic qualities and high folding endurance. Patches with consistently high moisture uptake (around 40%) were observed to contain high concentration of cassava starch while those with higher amounts of HPMC lost more water (around 35%). The ex vivo study showed efficient permeation and flux for the target purpose. Conclusion: Transdermal patches may be used to deliver low dose chlorpheniramine drug through the skin possibly soft and thin infant skin.
Keywords: Transdermal; permeation; flux; allergy; chlorpheniramine
 Rumore MM, Clinical Pharmacokinetics of Chlorpheniramine, Annals of Pharmacotherapy, 1984; 18 (9):701-707
 Kumar A, Pullankandam N, Prabhu SL, Gopal V, Transdermal drug delivery: an overview, Int. J Pharm Sci. Review Res., 2010; 3(2): 49-54.
 Divya A, Rao MK, Gnanprakash K, Sowjanya A, Vidyasagar N, Gobinath M, A review on current scenario of transdermal drug delivery system, Int. J Res. Pharm Sci., 2012; 3(4):494-502
 Vieira MGA, da Silva MA, dos Santos LO, Beppu MM, Natural-based plasticizers and biopolymer films: A review, European Polymer Journal, 2011; 47(3):254-263
 Bodmeier R, Paeratakul O. Theophylline tablets coated with aqueous latexes containing dispersed pore formers. J. Pharm. Sci. 1990; 79:32.
 Rao PR, Reddy MN, Ramakrishna S, Diwan PV, Comparative in vivo evaluation of propranolol hydrochloride after oral and transdermal administration in rabbits, Eur. J. Pharm. Biopharm., 2003; 56:81–85
 Anderberg EK, Artursson P, Epithelial transport of drugs in cell culture 8. Effects of sodium dodecylsulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells, J. Pharm. Sci., 1993; 82:392–398.
 Agubata CO, Ottah OG, Development, characterization and ex vivo studies of transdermal patches for the delivery of diazepam using hypromellose, polyvinyl alcohol and cassava starch composite polymers, Journal of Pharmaceutical Development and Industrial Pharmacy, 2019; 1(1):1-9
 Singh A, Bali A, Formulation and characterization of transdermal patches for controlled delivery of duloxetine hydrochloride, Journal of Analytical Science and Technology, 2016; 7:25. DOI 10.1186/s40543-016-0105-6
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