Inclusion Complexation in Sulfobutyl Ether Beta Cyclodextrin and Dispersion in Gelucire for Sustained Release of Nifedipine Employing Almond Gum

  • Kanteti Venkata Ramesh RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences, University, Ras Al Khaimah, United Arab Emirates
  • Meena Achamma RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences, University, Ras Al Khaimah, United Arab Emirates
  • Hemant Kumar Yadav RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences, University, Ras Al Khaimah, United Arab Emirates
  • Tamer Salama Elmarsafawy RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences, University, Ras Al Khaimah, United Arab Emirates
  • Quamrul Islam RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences, University, Ras Al Khaimah, United Arab Emirates

Abstract

In the present research investigation, the utility of employing high dissolving forms of nifedipine for sustained release from matrix tablets with almond gum as major release retardant is explored. A poorly soluble BCS class II drug nifedipine is chosen as a model drug. Efforts were made to alter the dissolution characteristics of the drug before it is entrapped in the polymer matrix of almond gum. Inclusion complexation in sulfobutyl ether beta cyclodextrin or solid dispersion in gelucire (50/13) resulted in enhanced dissolution of nifedipine. The high dissolving forms are characterized by x-ray diffraction, differential scanning calorimetry and infra-red spectroscopy. The matrix tablets prepared employing the high dissolving forms exhibited satisfactory characteristics such as hardness, friability, swelling index. The drug release is found to be slow and spread over a period of 12 hours and the release could be modified with changes in nature of high dissolving form and the proportion of almond gum as the major release retardant. Employing high dissolving forms in matrix tablets of almond gum is found to be a novel approach in obtaining slow and complete release of poorly soluble drug such as nifedipine.


Keywords:  sulfobutyl ether beta cyclodextrin, solid dispersion, nifedipine

Downloads

Download data is not yet available.

References

1. Nowsheen G, Archana B. Naltrexone: A review of existing sustained drug delivery systems and emerging nano-based systems. J Control Release. 2014; 183:154-166.
2. Varaporn B, Junyapraserta G. Release profile comparison and stability of diltiazem–resin microcapsules in sustained release suspensions. Int J Pharm. 2008; 352(1):81-91.
3. Amidon GL, Lennerlas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995; 12:413-20.
4. Nixon, J.R., 1983. Release characterization of microcapsules. In: Lim, F. (Ed.), Biomedical Applications of Microcapsulation. CRC Press, Boca Raton, FL, p. 19. Peppas NA., Sahlin,
5. Benita S, Barkai A, Pathak YV. 1990. Effect of drug loading extent on the in vitro release kinetic behavior of nifedipine from polyacrylate microspheres. J. Control. Rel. 1990; 12:213.
6. AHFS Drug Information. 2018 published by American Society of Health System Pharmacists, p.2005-2012
7. Okimoto K, Rajewski RA, Uekama K, Jona JA, Stella VJ. The interaction of charged and uncharged drugs with neutral (HP-beta-CD) and anionically charged (SBE7-beta-CD) beta-cyclodextrins. Pharm Res. 1996; 13:256–1264
8. Sheng QI, Delphine M, Duncan QM. An Investigation into the Mechanism of Dissolution Rate Enhancement of Poorly Water-Soluble Drugs from Spray Chilled Gelucire 50/13 Microspheres J Pharm Sci 2010; 99(1):262-274
9. Dordunoo SK, Ford JL, Rubinstein MH. Solidification studies of polyethylene glycols, gelucire 44/14 or their dispersions with triamterene or temazepam. J Pharm Pharmacol 1996; 48:782–9
10. Bouaziz, F, Ben Romdhane, M et al. Healing efficiency of oligosaccharides generated from almond gum (Amygdalus communis) on dermal wounds of adult rats. J Tissue Viability. 2014; 23(3):98–108.
11. Sarojini A, Kunam DS, Manavalan R, Jayanthi B. Effect of natural almond gum as a binder in the formulation of diclofenac sodium tablets Int J Pharm Sci Res. 2010; 1(3):55-60.
12. Syed AH, Jaisankar V. An eco-friendly synthesis, characterization and antibacterial applications of novel almond gum – poly(acrylamide) based hydrogel silver nanocomposite Polym Test. 2017; 62 (10):1016 -1029.
13. Higuchi T, Connors A. Phase-solubility techniques. In: Advances in analytical chemistry instrumentation. New York, NY: Wiley Interscience; 1965; 117–211.
14. Carrier RL, Miller LA, Ahmed I. The utility of cyclodextrins for enhancing oral bioavailability. J Control Release. 2007; 123:78–99.
15. Khan KA. The concept of dissolution efficiency. J Pharm Pharmacol. 1975; 27:48–9.
16. Moore JW and Flanner HH. Mathematical comparison of dissolution profiles. Pharm. Tech. 1996; 20(6):64–75.
17. Ali SL, In Analytical Profiles of Drug Substances, K. Florey, Ed., Academic Press Inc., New York 1989, p. 221.
18. Mielcarek J, Sadaj A. Inclusion compounds of nifedipine and other 1, 4-dihydropyridine derivatives with cyclodextrins I. Complexation of nifedipine with –cyclodextrins Acta. Pol. Pharm 1994; 51:15.
19. Ghori, M.U, Conway, B.R. Hydrophilic matrices for oral control drug delivery. Am. J. Pharmacol. Sci. 2015; 3:103–109
20. Higuchi T. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963; 52(12):1145-1149.
21. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983; 15:25-35.
Statistics
53 Views | 59 Downloads
How to Cite
Ramesh, K., Achamma, M., Yadav, H. K., Elmarsafawy, T. S., & Islam, Q. (2019). Inclusion Complexation in Sulfobutyl Ether Beta Cyclodextrin and Dispersion in Gelucire for Sustained Release of Nifedipine Employing Almond Gum. Journal of Drug Delivery and Therapeutics, 9(6), 70-78. https://doi.org/10.22270/jddt.v9i6.3681