Contact Lenses: A Promising Drug Delivery System
Presently, around 100 million people are estimated to be wearing contact lenses, and the number is growing exponentially. Though the main use of contact lenses is for improving ametropia problems, they also hold attention as therapeutic devices for the treatment of ocular pain, promotion of corneal healing, maintenance of corneal epithelial hydration, and drug delivery. Contact lenses are developing as an substitute ophthalmic drug delivery system to resolve the problems of the conventional topical application methods [1,2]. The interest in evolving contact lenses for drug delivery has expressively increased in the last decade as several new techniques have been developed for designing contact lenses for extended drug delivery. The newest studies show that contact lenses are able to achieve prolonged release of a few weeks without any significant effect on critical lens properties. The future appears promising for drug eluting contact lenses but several challenges remain to be overcome regarding processing and storage issues, lack of use in the elderly population, regulatory issues, high costs of clinical studies and cost-benefit analysis. Contact lenses are attractive for ocular drug delivery systems as significantly prolong the residence time of the drug in the eye, high degree of comfort which improve patient compliance, higher efficiency and low side effects and, hence increase the ocular drug bioavailability.
Keywords: Lenses, polymer, methods, therapeutic, eye
2. Carmen Alvarez-Lorenzo, Haruyuki Hiratani and Angel Concheiro, Contact Lenses for Drug Delivery Achieving Sustained Release with Novel Systems, Am J Drug Deliv 2006; 4 (3)
3. K.-H. Hsu, S. Gause, A. Chauhan, Review of ophthalmic drug delivery by contact lenses, J. DRUG DEL. SCI. TECH., 24 (2) 123-135 2014
4. John W. Shell, Ophthalmic Drug Delivery Systems, Survey Of Ophthalmology, Volume 29 l Number 2. September-October1984
5. Patel PB, Shastri DH, Shelat PK, Shukla AK, Ophthalmic Drug Delivery System: Challenges and Approaches, Systematic Reviews in Pharmacy | July-December 2010 | Vol 1 | Issue 2
6. Dasom Lee1, Seungkwon Cho, Hwa Sung Park & Inchan Kwon, Ocular Drug Delivery through pHEMA-Hydrogel Contact Lenses Co-Loaded with Lipophilic Vitamins, Scientific Reports | 6:34194 | DOI: 10.1038/srep34194
7. Chau-Minh Phan, Alex Hui, Lakshman Subbaraman and Lyndon Jones, Insights to Using Contact Lenses for Drug Delivery, Journal of Clinical and Experimental Pharmacology, Phan et al., Clin Exp Pharmacol 2014, 4:1 DOI: 10.4172/2161-1459.1000145
8. Hitesh Gohel P., Ghadiyali Shahbaz, Viral Shah, Dr.U.M.Upadhyay, Drug Eluting Therapeutic Contact Lens, International Journal of Pharmaceutical Research & Allied Sciences, Volume 1, issue 4 (2012), 1-6, ISSN 2277-3657
9. Furqan A. Maulvi, Tejal G. Soni & Dinesh O. Shah, A review on therapeutic contact lenses for ocular drug delivery, Drug Delivery, 2016; 23(8): 3017–3026, 2016 Informa UK Limited, trading as Taylor & Francis Group. DOI: 10.3109/10717544.2016.1138342
10. Insan Sunan Kurniawansyah, Sriwidodo, Soraya Ratnawulan Mita, Krishnapriya Ravi, Drug Delivery System by Hydrogel Soft Contact Lens Materials: A Review, Journal of pharmaceutical sciences and research, Vol. 10(2), 2018, 254-256
11. Gourishanker Jha, Amit Kumar, Drug delivery through soft contact lenses: An introduction, Chronicles of Young Scientists, Vol. 2 | Issue 1 | Jan-Mar 2011
12. Seung Woo Choi and Jaeyun Kim Therapeutic Contact Lenses with Polymeric Vehicles for Ocular Drug Delivery: A Review, Materials 2018, 11, 1125; doi:10.3390/ma11071125
13.Anubhav Chavan, Ocular drug delivery role of contact lenses, Allied ophthalmic sciences, ISSN 0972-0200
14. Brian Pall, Paul Gomes, Frank Yi and Gail Torkildsen, , Management of Ocular Allergy Itch With an Antihistamine-Releasing Contact Lens, CLINICAL SCIENCE, Cornea _ Volume 00, Number 00, Month 2019
15. Pratik Swarup Das* and Puja Saha, Contact lenses: A development towards ocular drug delivery system, World Journal of Pharmaceutical Research,uVol 6, Issue 09, 2017.
16. Noha S El-Salamounia and Ragwa M Farida, Recent Drug Delivery Systems for Treatment of Glaucoma, Glaucoma | www.smgebooks.com
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