A REVIEW Sublingual Immunotherapy: An Innovative Alternative for Allergies
Sublingual Immunotherapy is a form of immunotherapy that involves placing the allergen extract under the tongue. An allergist gives patient small doses of an allergen under the tongue to boost the tolerance to the substance and reduce its symptoms. At present, the only forms of SLIT approved by the FDA are tablets for ragweed, northern pasture grasses like timothy, and dust mites. The safety and efficacy of allergy drops is yet being established by the FDA, and they are only used without label in the United States. The possible advantages of sublingual treatment are those of no use of injections, comparatively few regular doctor visits, possibility of home dosing after the first treatment, also a lower risk of serious reactions. Parents of young children often prefer sublingual immunotherapy as their child does not have to have regular injections. The main disadvantage of this form of treatment is its cost as more allergen needs to be swallowed than injected, this results in the cost per allergen being more expensive than that of injected treatments.
Keywords: Sublingual immunotherapy, allergies, SLIT, SCIT, AIT, allergen.
2. Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M et al. Sublingual immunotherapy. World Allergy Organization Journal 2014; 7:6
3. Albrecht KE, Valentine WJ, Christensen J, Vestenbaek U, Pamer AJ. Sublingual Immunotherapy in Allergic Rhinitis and Asthma: A Review of Recent Clinical Evidence. The Journal of Applied Research, 2007; 7(1):25-6
5. Cox LS, Linnemann DL, Nolte H et al. Sublingual immunotherapy: A Comprehensive Review. Mechanism of Asthma and Allergic Inflammation. 2006; 117:1021-35.
6. Harish, Ziv. PCT/US Patent, WO 2014/205008 A1.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).