A Review on Pharmacological Activities of Calotropis Procera
The plant Calotropis procera (Aiton) Dryand belong to the Apocynaceae family it is popularly known as “Rui” in Marathi, “ Mudar” in hindi other common name include Rubber Bush, Apple of sodom. (India & Pakistan). The bark and leaves are known to show wound healing, shows anti-Hyperglycemic effect, Analgesic, Anti pyretic, neuromuscular blocking activity, Purgative, anti-cancer activities. The phytochemistry of plant reveals presence of triterpenoids, flavonoids, cardiac glycosides, cardenolides, anthocyanins, α-amyrin, β-amyrin, lupeol, β-sitosterol, flavanols, mudarine, resins, a powerful bacteriolytic enzyme calactin, a nontoxic proteolytic enzyme calotropin, and a wax was isolated from the heartwood of Calotropis procera. The present review focuses on pharmacological activities of Calotropis procera.
Keywords: Calotropis procera, anti- Hyperglycemic effect, wound healing, pharmacological activities.
2. Al-Snafi AE. The Methods followed by Arabic physicians for treatment of cancer 4th Arabic Conf .of Medicinal Plants, Thamar Univ. Yemen 1999, 122-136.
3. Marbin MI, Al-Snafi AE, Marbut MM, Allahwerdy IY. The probable therapeutic effects of Date palm pollens in treatment of male infertility. Tikrit Journal of Pharmaceutical Sciences, 1 (1), 2005, 30-35.
4. Al-Snafi AE, Al-Samarai AGM, Al-Sabawi AM. The effectiveness of Nigella sativa seed oil in treatment of chronic urticaria. Tikrit Journal of Pharmaceutical Sciences, 1(1), 2005, 1-6.
5. Al-Snafi AE. The pharmacological importance of Casuarina equisetifolia - An overview. International Journal of Pharmacological Screening Methods, 5(1), 2015, 4-9.
6. Al-Snafi AE. The chemical constituents and pharmacological effects of Chenopodium album - An overview. International J of Pharmacological Screening Methods, 5(1), 2015, 10-17.
7. Al-Snafi AE, Bahaadeen EF, Marbeen MI, Marbut MM. The effect of date palm pollens and zinc sulphate in the treatment of human male infertility. Tikrit Journal of Pharmaceutical Sciences, 2(1), 2006, 31-34.
8. Al-Snafi AE. Encyclopedia of the constituents and pharmacological effects of Iraqi medicinal plants. Thi qar University, 2013.
09. Al-Snafi AE. The pharmacological importance of Ailanthus altissima- A review. International Journal of Pharmacy Review and Research, 5(2), 2015, 130-136.
10. Al-Snafi AE. Alhagi maurorum as a potential medicinal herb: An overview. International Journal of Pharmacy Review and Research, 5(2), 2015, 121-129.
11. Al-Snafi AE. The pharmacological importance of Aloe vera- A review. International Journal of Phytopharmacy Research, 5(2), 2015, 28-33.
12. Al-Snafi AE. The constituents and biological effects of Arundo donax - A review. International Journal of Phytopharmacy Research, 5(2), 2015, 34-40.
13. Al-Snafi AE. The nutritional and therapeutic importance of Avena sativa - An overview. International Journal of Phytotherapy, 5(2), 2015, 48-56.
14. The plant list. A working list of plant species, Calotropis procera. http://www.theplantlist.org/tpl/record/kew-2693660
15. Gupta S, Bhawani G, Karishma K, Pooja S. Ehnopharmaological potential of Calotropis procera : An overview. IRJP, 3(12), 2012, 19-22.
16. Sharma AK, Kharab R, Kaur R. Pharmacognostical aspects of Calotropis procera (Ait.) R. Br. International Journal of Pharma and Bio Sciences, 2(3), 2011, B480-B488.
17. Orwa C, Mutua A, Kindt R, Jamnadass R, Simons A. Agroforestree Database: a tree reference and selection guide version, 2009, http://www.world agroforestry.org/af/treedb/
18. El Bsma Adam SEI. Studies on laticiferous plants: Toxic effects in goats on Calotropis procera latex given by different routes of administration, Deutsche Tieraerztliche Wochenschrift, 105(11), 1988, 425-427,
19. Jain SC, Sharma R. Antimicrobial activity of Calotropis procera, Fitoterapia. 67(3), 1996, 275- 276.
20. 53. Ramos MV, Araújo ES, Jucá TL, Monteiro-Moreira AC, Vasconcelos IM, Moreira RA, Viana CA, Beltramini LM, Pereira DA, Moreno FB. New insights into the complex mixture of latex cysteine peptidases in Calotropis procera. Int J Biol Macromol, 58, 2013, 211-219.
21. 54. Kumar S, Gupta A, Pandey AK. Calotropis procera root extract has the capability to combat free radical mediated damage. ISRN Pharmacol, 2013, doi: 10.1155/2013/691372.
22. Kumar S, Gupta A, Pandey AK. Calotropis procera root extract has the capability to combat free radical mediated damage. ISRN Pharmacol, 2013, doi: 10.1155/2013/691372.
23. Moronkola DO, Ogukwe C, Awokoya KN. Chemical compositions of leaf and stem essential oils of Calotropis procera Ait R.Br [Asclepiadaceae]. Der Chemica Sinica, 2 (2), 2011, 255-260.
24. Bouratoua A, Khalfallah A, Kabouche A, Semza Z, Kabouche Z. Total phenolic quantification, antioxidant, antibacterial activities and flavonoids of Algerian Calotropis procera (Asclepiadaceae). Der Pharmacia Lettre, 5 (4), 2013, 204-207.
25. Yesmin MN, Uddin SN, Mubassara S, Akond MA. Antioxidant and antibacterial activities of Calotropis procera Linn. American-Eurasian J Agric & Environ Sci, 4 (5), 2008, 550-553.
26. Halu B, Vidyasagar GM. A comparative study: differential antimycoses activity of crude leaf extracts of Calotropis Spp. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3), 2012, 705-708.
27. Freitas CD, Lopes JL, Beltramini LM, de Oliveira RS, Oliveira JT, Ramos MV. Osmotin from Calotropis procera latex: new insights into structure and antifungal properties. Biochim Biophys Acta, 8(10), 2011, 2501-2507.
28. Murti Y, Singh A, Pathak D. In vitro anthelmintic and cytotoxic potential of different extracts of Calotropis procera leaves. Asian J Pharm Clin Res, 6(1), 2013, 14-15.
29. Sighi M, Purohit AA. Studies on comparative larvicidal efficacy of methanol extracted latex of Calotropis procera and Temephos against Aedes aegypti in arid parts of Rajasthan. RJPBCS, 4(4), 2013, 1139-1142.
30. Dewan S, Kumar S, Kumar VL. Antipyretic effect of latex of Calotropis procera. Indian Journal of Pharmacology, 32, 2000, 252.
31. Patil RA1, Makwana AB, Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.2015, 161262
32. Rahmatullah M1, Sultan S, Toma TT, Lucky SA, Chowdhury MH, Haque WM, Annay EA, Jahan R.Effect of Cuscuta reflexa stem and Calotropis procera leaf extracts on glucose tolerance in glucose-induced hyperglycemic rats and mice.,2009 109-12
33. Oliveira JS1, Costa-Lotufo LV, Bezerra DP, Alencar NM, Marinho-Filho JD, Figueiredo IS, Moraes MO, Pessoa C, Alves AP, Ramos MV.In vivo growth inhibition of sarcoma 180 by latex proteins from Calotropis procera.2010 139-49
34. Awaad AA1, Alkanhal HF1, El-Meligy RM2, Zain GM3, Sesh Adri VD4, Hassan DA4, Alqasoumi SI5.Anti-ulcerative colitis activity of Calotropis procera Linn.,2018,75-78
35. Kamath JV1, Rana AC.Preliminary study on antifertility activity of Calotropis procera roots in female rats.2002, 111-5.
36. Kumar VL1, Guruprasad B1, Chaudhary P1, Fatmi SM1, Oliveira RS2, Ramos MV3.Protective effect of proteins derived from Calotropis procera latex against acute inflammation in rat.2015, 1-8
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