FORMULATION AND IN-VITRO EVALUATION OF FLOATING PULSATILE DRUG DELIVERY SYSTEM OF IVABRADINE
The aim of present investigation was to develop press coated tablets for Floating pulsatile drug delivery of Ivabradine used for is a medication used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers. The drug delivery system was designed to deliver the drug such a time when it could be needful of patient conditions. The press coated tablets containing Ivabradine in the inner core were formulated by direct compression method with an outer coating of different amount of HPMCK200 M. The release profile of press coated tablet exhibited a lag time. The optimized batch F9 gave good drug release of 99.58 %.
Key words: Ivabradine, Eudragit, EC, HPMCK200M
2. Ramesh D, Parmar, Rajesh K, Parikh, Vidyasagar G, Dhaval, Pulsatile drug delivery systems, International journal of pharmaceutical sciences and nanotechnology, 2014; 8(10):605-611.
3. Hiralal S. Chaudhari, Mahadev S. Lohar, Amol S. Amritkar, Dinesh K. Jain, Dheeraj T. Baviskar, Pulsatile drug delivery system, International journal of pharmaceutical sciences review and research, 2011; 8(2):160-169.
4. S. Keerthi, Vijay Bhaskar Reddy, Gopal Muralidharan, Formulation and evaluation of pulsatile drug delivery system of anti-asthmatic drug, Am. J. Pharmtech res., 2014; 4(1):797-809.
5. Chikhalikar SS, Wakade RB, Floating Drug Delivery System - An Approach to Oral Controlled Drug Delivery, International Journal of Pharm. Tech Research, 2012; 4(4):1812-26.
6. Tripathi GK, Singh S, Formulation and In-vitro evaluation of pH sensitive oil entrapped polymeric blended buoyant beads of Amoxicillin, Scholars Research Library, 2010; 2 (2):131-38.
7. Burns SJ, Attwood D, Barnwell SG, Assessment of a dissolution vessel designed for use with floating and erodible dosage forms, International Journal of Pharmaceutics, 1998; 160:213–18.
8. Kharia A.A, Hiremath SN, Singhai AK, Jain SK, Design and optimization of floating drug delivery system of acyclovir, Indian Journal of Pharmaceutical Sciences, 2010; 72(5):599-606.
9. Mathur P, Verma N, Floating drug delivery system: An innovative acceptable approach in gastroretentive drug delivery, Scholars Research Library, 2010; 2(2):257-70.
10. Chandel A, Chauhan K, Parashar B, Kumar H and Arora S: Floating drug delivery systems: A better approach. International Current Pharmaceutical Journal 2012; 1(5):110-18.
11. Shah SH, Patel JK, Patel NV, Stomach specific floating drug delivery system: A review, International Journal of Pharmaceutical Technology and Research, 2009; 1(3):623-33.
12. Gopalakrishnan S, Chenthilnathan A, Floating drug delivery system: A review, Journal of Pharmaceutical Science and Technology, 2011; 3(2): 548- 54.
13. Vedha H, Chaudhary J, The recent developments on gastric floating drug delivery system: An overview, Journal of Pharmaceutical Technology and Research, 2010; 2(1):524-34.
14. Arunachalam A, Kishan GK, Floating drug delivery system: A review, International Journal of Research in Pharmaceutical Sciences, 2011; 2(1): 76-78.
15. Sinduri P, Vyshali P, Formulation and In-Vitro Evaluation of Pulsatile Drug Delivery Tablets of Zaltoprofen, International Research Journal of Pharmaceutical and Biosciences, 2017; 4 (2):8-17.
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