Enhancement of Sulfamethoxazole by Solid Dispersion using Spray Dryer Technique
The aim of this study was to enhance the solubility of SMZ by preparing solid dispersion using a spray dryer. Different polymers were used to study their effect on the solubility of SMZ. Effect of polymer on solubility of drug in the form of solid dispersion was studied by determining the solubility of each solid dispersion separately. It was observed that solubility of drug changes with change in the polymer. As a result of this study, it was found that solubility of SMZ was significantly enhanced by solid dispersion with the polymers especially with the PVP K30 and HPMC E15.
Keywords SMZ, Solubility, Solid dispersion, Spray dryer.
2: Bhusnure OG, Kazi PA, Gholve, MMAW Ansari And SN Kazi. Solid Dispersion: An Ever Green Method For Solubility Enhancement Of Poorly Water Soluble Drugs. International Journal Of Research In Pharmacy And Chemistry. 4(4) 906-918
3: IARC Monograph Volume 79
4: Bibi F. Choonara, Yahya E. Choonara, Praddep Kumar, Lisa C Du Toit, Lomas K. Tomar, Charu Tyagi, And Viness Pillay. A Menthol Based Solid Dispersion Technique Fo Enhanced Solubility And Dissolution Of Sulfamethoxazole From An Oral Tablet Matrix. AAPS Pharmscitech Vol 16 No 4
5: Sareen S, Mathew G, Joseph L. Improvement In Solubility Of Poor Water Soluble Drugs By Solid Dispersion. International Journal of Pharmaceutical Investigation Vol 2 12-17
6: Maheshwari R K , Jagwani Y. Mixed Hydrotropy:Novel Science Of Solubility Enhancement. Indian Journal of Pharmaceutical Science. Pharm Sci 673(2):179-183
7: Erizal Zaini, Yeyet C Sumirtapura, Auzal Halim, Lili Fitriani, Sundani N. Soewandhi. Formation And Characterization Of Sulfamethoxazole-Trimethoprim Cocrystal By Milling Process. Journal Of Applied Pharmaceutical Science Vol 7 (12) 169-173
8: Dixit M, Rasheed A, Charyulu N, Rahman F, Daniel S. Enhancing Solubility And Dissolution Of Fenofibrate By Spray Drying Technique. International Journal of Pharmacy And Pharmaceutical Science. Pharm Sci Vol 7 173-177
9: Pourmokhtar M, Jacobson GA. Enhanced Stability Of Sulfamethoxazole And Trimethoprim Against Oxidation Using Hydroxyl-Β-Cyclodextrin. Pharmazie 60 (2005) 11
10: Sisodiya M, Saudagar R. Solubility Enhancement Formulation Development and Evaluation Of Immediate Release Tablet Of Antihypertensive Drug Tadafil. Journal of Drug Delivery and Therapeutics 2018; 8(5):294-304
11: Win Lounge Chiou And Sidney Riegelman. Pharmaceutical Application of Solid Dispersion System. Journal of Pharmaceutical Science Vol 60 1281-1302
12: Pjuong Tran, Yong Chul Pyo, Dong-Hyun Kim, Sang-Eun Lee, Jin- Ki Kim, and Jeong- Sook Park. Overview Of The Manufacturing Methods Of Solid Dispersion Technology For Improving The Solubility Of Poorly Water-Soluble Drugs And Application To Anticancer Drugs. MDPI.
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