Enhancement of Sulfamethoxazole by Solid Dispersion using Spray Dryer Technique
The aim of this study was to enhance the solubility of SMZ by preparing solid dispersion using a spray dryer. Different polymers were used to study their effect on the solubility of SMZ. Effect of polymer on solubility of drug in the form of solid dispersion was studied by determining the solubility of each solid dispersion separately. It was observed that solubility of drug changes with change in the polymer. As a result of this study, it was found that solubility of SMZ was significantly enhanced by solid dispersion with the polymers especially with the PVP K30 and HPMC E15.
Keywords SMZ, Solubility, Solid dispersion, Spray dryer.
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