Enhancement of Sulfamethoxazole by Solid Dispersion using Spray Dryer Technique

  • Pravin Gadakh Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India
  • Surup Singh Valvi Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India
  • Shubham Jagatp Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India
  • Amol Gomase Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Abstract

The aim of this study was to enhance the solubility of SMZ by preparing solid dispersion using a spray dryer. Different polymers were used to study their effect on the solubility of SMZ. Effect of polymer on solubility of drug in the form of solid dispersion was studied by determining the solubility of each solid dispersion separately. It was observed that solubility of drug changes with change in the polymer. As   a result of this study, it was found that solubility of SMZ was significantly enhanced by solid dispersion with the polymers especially with the PVP K30 and HPMC E15.


Keywords SMZ, Solubility, Solid dispersion, Spray dryer.

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Author Biographies

Pravin Gadakh, Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Surup Singh Valvi, Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Shubham Jagatp, Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Amol Gomase, Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

Amrutvahini College of Pharmacy, Department of Pharmaceutics Sangamner Maharashtra, India

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How to Cite
Gadakh, P., Valvi, S. S., Jagatp, S., & Gomase, A. (2019). Enhancement of Sulfamethoxazole by Solid Dispersion using Spray Dryer Technique. Journal of Drug Delivery and Therapeutics, 9(3-s), 76-79. https://doi.org/10.22270/jddt.v9i3-s.2796