Evaluation and Comparative study of Lens Aldose Reductase Inhibitory activity of leaves Extracts of Merremia emarginata, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata: Potential for Diabetic Cataract treatment
Introduction: The present research attempts at discovering an effective anti-cataract agent, focusing on evaluation of Aldose reductase inhibition (ARI) capacities of weeds and lichen. The present study was aimed at finding out the in vitro ARI activity of extracts of weed plants and lichen. Methods: ARI activities of the ethanolic extract of weed plants and lichen were evaluated using goat lens aldose reductase using Hayman and Kinoshita method. Evaluation was done using UV-Visible spectroscopy at 340 nm. Results: The extracts showed AR inhibitory activity at different extent. Conclusion: The study concludes the ARI capacity of leaves of Merremia emarginata, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata which may be attributed to their flavonoid constituents and their extraction are solvent dependent. Thus Merremia emarginata leaves, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata weed plant’s leaves and lichen may therefore work as a base for the development of anticataract agent. And out of all extract Triadax procumbens showed maximum activity.
Keywords: Aldose reductase, Merremia emarginata leaves, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata anti-cataract agent, weed plant, lichen, flavonoid.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).