Evaluation and Comparative study of Lens Aldose Reductase Inhibitory activity of leaves Extracts of Merremia emarginata, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata: Potential for Diabetic Cataract treatment

  • Thomson Alex
  • Shabnam Mansuri
  • Gyaneshwar Dongre
  • Arvind Mandloi
  • Kushagra Dubey
  • Neelesh Malviya

Abstract

Introduction: The present research attempts at discovering an effective anti-cataract agent, focusing on evaluation of Aldose reductase inhibition (ARI) capacities of weeds and lichen. The present study was aimed at finding out the in vitro ARI activity of extracts of weed plants and lichen. Methods: ARI activities of the ethanolic extract of weed plants and lichen were evaluated using goat lens aldose reductase using Hayman and Kinoshita method. Evaluation was done using UV-Visible spectroscopy at 340 nm. Results: The extracts showed AR inhibitory activity at different extent. Conclusion: The study concludes the ARI capacity of leaves of Merremia emarginata, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata which may be attributed to their flavonoid constituents and their extraction are solvent dependent. Thus Merremia emarginata leaves, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata weed plant’s leaves and lichen may therefore work as a base for the development of anticataract agent. And out of all extract Triadax procumbens showed maximum activity.


Keywords: Aldose reductase, Merremia emarginata leaves, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata anti-cataract agent, weed plant, lichen, flavonoid.

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Alex T, Mansuri S, Dongre G, Mandloi A, Dubey K, Malviya N. Evaluation and Comparative study of Lens Aldose Reductase Inhibitory activity of leaves Extracts of Merremia emarginata, Permotrema perlatum, Tridax procumbens and Euphorbia prostrata: Potential for Diabetic Cataract treatment. JDDT [Internet]. 25Apr.2019 [cited 20Oct.2020];9(2-A):87-8. Available from: http://jddtonline.info/index.php/jddt/article/view/2788

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