Role of naturally isolated pear starch on the bioavailability of famotidine

  • Anjali Kushwaha School of Pharmacy, BBD University, Lucknow, U.P., India
  • Pratap Manjul Singh School of Pharmacy, BBD University, Lucknow, U.P., India

Abstract

Purpose- The bioavailability of any drug in the formulation is affected by various excipients presents in it.  In case of tablets the role of binders is very important for dissolution of dosage form as well as bioavailability of drug. Thus in following study an attempt is made to improve the dissolution of drug by using pear starch as binding agents. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and then evaluate them.


 Methods-The tablets were formulated by wet granulation method by using 2% w/v, 4% w/v, 6% w/v and 8% w/v of pear starch as binding agent. Then formulated famotidine tablets were further evaluated for various parameters i.e. weight variation, hardness, friability, disintegration time and in-vitro drug release and in vivo study.


Results-The hardness and disintegration time of the tablets was found to be increased with increase in starch concentration. Tablets with highest binder concentration showed maximum hardness 6.5 kg) and disintegration time (10 min) and minimum friability (0.48%). After one hour tablets with 4% w/v starch showed maximum drug release (80.69%). The optimized formulation then go for in vivo study, shows better bioavailability as compares to marketed one. Hence isolated starch shows increase in the dissolution and bioavailability, when used as binder in tablet formulations.


Conclusions- The results from various evaluations show that pear starch has significant binding characteristics. Hence it can be used as tablet binder in pharmaceutical formulations for future aspects.


Keywords: Starch, binder, tablets, in-vitro dissolution, famotidine

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Author Biographies

Anjali Kushwaha, School of Pharmacy, BBD University, Lucknow, U.P., India

School of Pharmacy, BBD University, Lucknow, U.P., India

Pratap Manjul Singh, School of Pharmacy, BBD University, Lucknow, U.P., India

School of Pharmacy, BBD University, Lucknow, U.P., India

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How to Cite
Kushwaha, A., & Singh, P. M. (2019). Role of naturally isolated pear starch on the bioavailability of famotidine. Journal of Drug Delivery and Therapeutics, 9(3), 430-435. https://doi.org/10.22270/jddt.v9i3.2704