Role of naturally isolated pear starch on the bioavailability of famotidine

  • Anjali Kushwaha School of Pharmacy, BBD University, Lucknow, U.P., India
  • Pratap Manjul Singh School of Pharmacy, BBD University, Lucknow, U.P., India


Purpose- The bioavailability of any drug in the formulation is affected by various excipients presents in it.  In case of tablets the role of binders is very important for dissolution of dosage form as well as bioavailability of drug. Thus in following study an attempt is made to improve the dissolution of drug by using pear starch as binding agents. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and then evaluate them.

 Methods-The tablets were formulated by wet granulation method by using 2% w/v, 4% w/v, 6% w/v and 8% w/v of pear starch as binding agent. Then formulated famotidine tablets were further evaluated for various parameters i.e. weight variation, hardness, friability, disintegration time and in-vitro drug release and in vivo study.

Results-The hardness and disintegration time of the tablets was found to be increased with increase in starch concentration. Tablets with highest binder concentration showed maximum hardness 6.5 kg) and disintegration time (10 min) and minimum friability (0.48%). After one hour tablets with 4% w/v starch showed maximum drug release (80.69%). The optimized formulation then go for in vivo study, shows better bioavailability as compares to marketed one. Hence isolated starch shows increase in the dissolution and bioavailability, when used as binder in tablet formulations.

Conclusions- The results from various evaluations show that pear starch has significant binding characteristics. Hence it can be used as tablet binder in pharmaceutical formulations for future aspects.

Keywords: Starch, binder, tablets, in-vitro dissolution, famotidine


Download data is not yet available.

Author Biographies

Anjali Kushwaha, School of Pharmacy, BBD University, Lucknow, U.P., India

School of Pharmacy, BBD University, Lucknow, U.P., India

Pratap Manjul Singh, School of Pharmacy, BBD University, Lucknow, U.P., India

School of Pharmacy, BBD University, Lucknow, U.P., India


1. Singh AV, Nath LK. Evaluation of chemically modified hydrophobic sago starch as a carrier for controlled drug delivery. Saudi Pharmaceutical Journal, 2013; 21(2):193-200.
2. Hussain A, Qureshi F, Abbas N, Arshad MS, Ali E. An evaluation of the binding strength of okra gum and the drug release characteristics of tablets prepared from it.Pharmaceutics, 2017; 9(2):20.
3. Hartesi B, Sriwidodo, Abdassah M, Chaerunisaa AY. Starch as Pharmaceutical Excipient. Int. J. Pharm. Sci. Rev. Res, 2016; 41(2):59-64.
4. Bamania BN, Chandur Y, Makadiya P, Shabaraya R. Formulation and Evaluation of Fast Dissolving Famotidine Solid Dispersion Tablet.A erican Journal of PharmTech Research. 2013; 3(5): 2249-3387.
5. Debnath S, Gayathri V.G., Niranjan Babu M. Chemically modified starches and their applications in pharmacy.International Journal of Research in Pharmaceutical and Nano Sciences, 2013; 2(3):332 -344.
6. Ebere I. Okoye, Austinline C. Ekweogu, Ugochukwu E.Oruna. Effects of palm bunch potash, trona and their modified cashew gum-corn starch composite on the physicochemical properties of furosemide. Journal of Pharmacy & Pharmacognosy Research 2017; 5(1):15-28.
7. Gangwar Satyam, Singh Shivani, Gangwar Shivam Jain Shobhit, Verma Sanjeev, Kumar Arvind. Starch as a material for drug delivery. International Journal of Biological & Pharmaceutical Research 2010; 1(2):56-60.
8. Gangwar Satyam, Singh Shivani, Garg Garima, Sharma Nitin, Sharma P.K. Isolation and evaluation of binding property of pappaya starch in diclofenac sodium tablet. International Journal of PharmTech Research2(2):1508-1512.
9. Ibezim, E. C., Ofoefule, S. I., Omeje, E. O., Onyishi V. I. and Odoh, U. E.The role of ginger starch as a binder in acetaminophen tablets.Academic Journal, 2008; 3(2):046-050
10. Indian Pharmacopoeia,3rd Edition, Government of India ,Ministry of Health and Family Welfare , New Delhi,1985,480, 501, A-122.
11. Indian Pharmacopoeia, 4th Edition, Government of India, Ministry of Health and Family Welfare, New Delhi, 1966,556.
12. Indian Pharmacopoeia. 4th Edition, Government of India, Ministry of Health and Family Welfare.New Delhi.1996. 692, 711.
13. Chitedze J, Monjerezi M, Kalenga Saka JD, Steenkamp J. Binding effect of cassava starches on the compression and mechanical properties of Ibuprofen tablets. Journal of Applied Pharmaceutical Science, 2012; 02(04):31-37
14. Kolawole SA, Igwemmar NC, Bello HA. Comparison of the physicochemical properties of starch from ginger (Zingiber officinale) and Maize (Zea mays), International Journal of Science and Research, 2013;2(11):71-76.
15. Kumar A. Importance for life Psidium guava. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2012; 3(1):137-148.
16. Martin A. Physical Pharmacy. 4th Edition.B.I. Waverly. New Delhi.1993. 444.
17. Ahmad N, Hasan N, Ahmad Z, Zishan M, Zohrameena S, Momordica charantia: for traditional uses and pharmacological actions. Journal of Drug Delivery and Therapeutics, 2016; 6(2):40-44.
18. Muhammad Usman, M. Tahir Ishfaq, Dr. Shahid Raza Malik, Muhammad Iqbal, and Bushra Ishfaq, (2014). Alkaline extraction of starch from broken rice of pakistan. International Journal of Innovation and Applied Studies, 2014; 7(1):146-152.
19. Patel S, Agrawal S, Lodhi BS. Natural binding agents in tablet formulation. International Journal of Pharmaceutical & Biological Archives, 2012; 3(3):466-473.
20. Puri A. V., Puranik V.K., Kamble M. D., Tauro S. J. Formulation and evaluation of diclofenac sodium tablet using isolated starch from unripe papaya fruits as disintegrants. Indo American Journal of Pharmaceutical Research 2013; 3(11):9183-9189.
21. Manchanda R, Shrivastava B, Arora SC, Manchanda R. Formulation, evaluation and optimization of tamarind seed polysaccharide based glipizide sustained release matrix tablets by 32 full factorial design. International Journal of PharmTech Research, 2015; 7(2):380-391.
22. Barad R, Soni P, Upadhyay S, Upadhyay U. Withania coagulans and Psidium guajava- an overview. International Research Journal of Pharmaceutical and Applied Sciences, 2013; 3(3):42-47.
23. Jaya S, Chowdary K.P.R., Rajeswara Rao P. Effect of binders on the dissolution rate and dissolution efficiency of ritonavir tablets.Int. Res J Pharm. App Sci., 2013; 2(5):224-229.
24. Apeji YE, Oyi AR, Musa H. Studies on the physicochemical properties of microcrystalline starch obtained by enzymatic hydrolysis using α-amylase enzyme. Pharmacophore (An International Research Journal). 2011; 2(1):9-15.
18 Views | 32 Downloads
How to Cite
Kushwaha, A., & Singh, P. M. (2019). Role of naturally isolated pear starch on the bioavailability of famotidine. Journal of Drug Delivery and Therapeutics, 9(3), 430-435.