Preparation and evaluation of sulfamethoxazole solid dispersion employing starch citrate-a new solubility enhancer

  • Rada Santosh Kumar GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India
  • Annu Kumari GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

Abstract

Sulfamethoxazole used widely as a broad spectrum antibiotic. However, its solubility and dissolution rate is very low due to poor solubility in water. Solid dispersion technique was selected for the current research to improve solubility and drug absorption from of Sulfamethoxazole. A new solubility enhancer starch citrate was selected prepared and characterized for its solubility, viscosity, swelling index, gelling property, particle size, etc. Prepared Sulfamethoxazole solid dispersion was evaluated for drug content and in vitro dissolution.


Keywords: Sulfamethoxazole, Starch citrate, Solid dispersion & In vitro study.

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Author Biographies

Rada Santosh Kumar, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

Annu Kumari, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam, A.P-530045, India

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How to Cite
Santosh Kumar, R., & Kumari, A. (2019). Preparation and evaluation of sulfamethoxazole solid dispersion employing starch citrate-a new solubility enhancer. Journal of Drug Delivery and Therapeutics, 9(2-s), 237-242. https://doi.org/10.22270/jddt.v9i2-s.2655