Evaluation of Anxiolytic Activity of Pitavastatin in Male Albino Mice

  • Premkumar Chiluveru Nottingham Trent University, Clifton campus, Nottingham, NG11 8NS
  • G. Thirupathi Vaagdevi Pharmacy College, Bollikunta, Warangal, India
  • T. Ravi Chander Vaagdevi Pharmacy College, Bollikunta, Warangal, India

Abstract

To assess the anxiolytic activity of Pitavastatin in male albino mice. To compare the anxiolytic activity of Pitavastatin with standard drug as diazepam. Anxiety is an emotional state, unpleasant in nature, associated with uneasiness, discomfort and fear about something.  This Anxiety higher in developed countries than developing countries, moreover womens are more prone to this. At present we find number of marketed drugs all that are producing somewhat tolerated compounds. As by with that condition we conducted this study comparison with  pitavastatin with diazepam. Pitavastatin and Diazepam were dissolved in saline. Control group mice were injected with saline. All drugs and saline were injected intraperitoneally, placed all in plus maze method and collected the data. Elevated plus maze Pitavastatin at dose 30 mg/kg and 50mg/kg increased number of open arm and total arm entries, time spent in open arm and decreased time spent in closed arm. The results suggest that the significant dose-dependent antianxiety activity of Pitavastatin is similar to the behavioral effects of Diazepam.


Keywords: Anxiolytic activity, Pitavastatin, Diazepam.

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Author Biographies

Premkumar Chiluveru, Nottingham Trent University, Clifton campus, Nottingham, NG11 8NS

Nottingham Trent University, Clifton campus, Nottingham, NG11 8NS

G. Thirupathi, Vaagdevi Pharmacy College, Bollikunta, Warangal, India

Vaagdevi Pharmacy College, Bollikunta, Warangal, India

T. Ravi Chander, Vaagdevi Pharmacy College, Bollikunta, Warangal, India

Vaagdevi Pharmacy College, Bollikunta, Warangal, India

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How to Cite
Chiluveru, P., Thirupathi, G., & Ravi Chander, T. (2019). Evaluation of Anxiolytic Activity of Pitavastatin in Male Albino Mice. Journal of Drug Delivery and Therapeutics, 9(3), 269-271. https://doi.org/10.22270/jddt.v9i3.2648