Evaluation of Anxiolytic Activity of Pitavastatin in Male Albino Mice
Abstract
To assess the anxiolytic activity of Pitavastatin in male albino mice. To compare the anxiolytic activity of Pitavastatin with standard drug as diazepam. Anxiety is an emotional state, unpleasant in nature, associated with uneasiness, discomfort and fear about something. This Anxiety higher in developed countries than developing countries, moreover womens are more prone to this. At present we find number of marketed drugs all that are producing somewhat tolerated compounds. As by with that condition we conducted this study comparison with pitavastatin with diazepam. Pitavastatin and Diazepam were dissolved in saline. Control group mice were injected with saline. All drugs and saline were injected intraperitoneally, placed all in plus maze method and collected the data. Elevated plus maze Pitavastatin at dose 30 mg/kg and 50mg/kg increased number of open arm and total arm entries, time spent in open arm and decreased time spent in closed arm. The results suggest that the significant dose-dependent antianxiety activity of Pitavastatin is similar to the behavioral effects of Diazepam.
Keywords: Anxiolytic activity, Pitavastatin, Diazepam.
DOI
https://doi.org/10.22270/jddt.v9i3.2648References
Rao EV. Modern approaches to herbal medicine. East Pharmacist, 2000; 5:35-38.
Sagrawat H, Mann AS, Kharya MD. Pharmacological potential of Eugenia jambolana, A review. Pharmacog. Mag. 2006; 2(6):96 -105.
Martin KP, Benna MR, Joseph D. High frequency axillary bud multiplication and ex - vitro rooting of Wedelia chinensis (Osbeck) Merr, A medicinal plant. Ind. J Exp. Biol. 2003; 41(3):262 -266.
Kirtikar KR, Basu BD. Indian Medicinal Plants. Dehradun, International book distributors, 2006, 1364 -1345.
Anonymous. A Dictionary Indian Raw Materials and Industrial Products, The Wealth of India, Raw Materials, Council of Scientific and Industrial Research, 2005, 567 -568.
Anonymous. The Wealth of India, Raw Materials, Publication and Information Directorate, New Delhi, 1948, 687 -688.
Suresh V, Kumar RM, Suresh A, Kumar NS, Arunachalam G, Umasankar Kl, CNS activity of ethanol extract of Wedelia chinensis in experimental animals. Int J Pharm. Sci. Nanotechnol. 2010; 3(1):881 - 886.
Mathew KM. Flora of Tamilnadu -carnatic. Trichirapalli, St. Josephs College, 1983, 392.
Linn SC, Linn CC, Linn YH, Shyuu SJ. Hepatoprotective effect against liver injuries. Ame. J Chin. Med. 1994; 22(3):155 -168.
Manjamalai A, Shakur AS, Haridas A, Berlin G. Evaluation of antifungal and anti - inflammatory effects on methanolic extract of Wedelia chinensis, Int J Pharm. Biol. Res. 2011; 2(1):30 -37.
Yang LL, Yen KY, Kiso Y, Hikino H. Antihepatotoxic actions of Formosan plant drugs. J Ethanopharmacol. 1987; 19 :103 -10.
Pate RM, Patel NJ. In vitro antioxidant activity of coumarin compounds by DPPH, super oxide and nitric oxide free radical scavenging methods. J Adv. Pharm. Edu. Res. 2011; 1:52 -68.
Published
Abstract Display: 517 
PDF Downloads: 503 How to Cite
Issue
Section
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
.