Formulation and In-vitro evaluation of liposomal drug delivery system of metformin HCl

  • Subbramanian L Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.
  • M Anitha Rani Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.
  • T Rajasekaran Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.
  • M Ramanathan Department of Pharmaceutics, Pannai College of Pharmacy, Dindigul - 624 005, Tamil Nadu, India.
  • P Solairaj Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

Abstract

Metformin is widely used for the treatment of diabetes; the intention of the present study was to formulate Metformin HCl liposomes for a sustained drug delivery system. It have the advantages of dose reduction, less dosing frequency, minimize the side effect, prolong the action of drug and thus achieve better patient compliance. The liposomes were prepared by physical dispersion and ether injection method. Soya lecithin and cholesterol were used for encapsulating the drug, it facilitates to release the medicaments in sustained manner. Chloroform, ether and methanol were used as a solvent. Phosphate buffer pH 6.8 was used as a hydration medium for loading the drug. The final liposome was evaluated in various quality parameters of drug entrapment efficiency, morphological analysis, particle size analysis, in-vitro drug release studies and stability studies. In the two methods of metformin liposome formulation the ether injection method showed prolonged action when compared to physical dispersion method. In the parameters of drug entrapment and stability physical dispersion method was shows better results.


Keywords: Physical dispersion, ether injection, soya lecithin, cholesterol, morphological analysis, metformin.

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Author Biographies

Subbramanian L, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

M Anitha Rani, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

T Rajasekaran, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

M Ramanathan, Department of Pharmaceutics, Pannai College of Pharmacy, Dindigul - 624 005, Tamil Nadu, India.

Department of Pharmaceutics, Pannai College of Pharmacy, Dindigul - 624 005, Tamil Nadu, India.

P Solairaj, Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi - 626130, Tamil Nadu, India.

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How to Cite
L, S., Anitha Rani, M., Rajasekaran, T., Ramanathan, M., & Solairaj, P. (2019). Formulation and In-vitro evaluation of liposomal drug delivery system of metformin HCl. Journal of Drug Delivery and Therapeutics, 9(2), 31-37. https://doi.org/10.22270/jddt.v9i2.2458